OSU Laboratory publications:
Adolescent prefrontal cortex and maturation of social and cognitive functions:
Bee S, Ringland A, Coutellier L. (2021) Social impairments in mice lacking the voltage-gated potassium channel Kv3.1. Behav Brain Res. 413:113468.
Shepard R, Heslin K, Hagerdorn P, Coutellier L. (2019) Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: relevance for schizophrenia. Translational Psychiatry. In press.
Page CE, Coutellier L. (2018). Adolescent stress disrupts the maturation of anxiety-related behaviors and alters the developmental trajectory of the prefrontal cortex in a sex- and age-specific manner. Neuroscience. 390:265-277
Page CE, Coutellier L. (2018) Reducing inhibition: A promising new strategy for the treatment of schizophrenia. EBioMedicine. 35:25-26.
Page CE, Alexander J, Shepard R, Coutellier L. (2018) Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility. Genes, Brain and Behavior. 17(6):e12459.
Heslin K, Coutellier L. (2018) Npas4 deficiency and prenatal stress interact to affect social recognition in mice. Genes Brain Behav. 17(5):e12448
Shepard R, Beckett E, Coutellier L. (2017) Assessment of the acquisition of executive function during the transition from adolescence to adulthood in male and female mice. Dev Cog Neurosci. 28: 29-40
Shepard R, Heslin K, Coutellier L. (2016) The transcription factor Npas4 contributes to adolescent development of prefrontal inhibitory circuits, and to cognitive and emotional functions: implications for neuropsychiatric disorders. Neurobiology of Disease. 99:36-46
Coutellier L, Gilbert V, Shepard R (2015) Npas4 deficiency increases vulnerability to juvenile stress in mice. Behavioral Brain Research. 295: 17-25
Adult prefrontal cortex and vulnerability to stress and psychopathologies:
Ganesh A, Choudhury W, Coutellier L (2024) Early spatial recognition memory deficits in 5XFAD female mice are associated with disruption of prefrontal parvalbumin neurons. Brain Research. 1841:149122.
Page CE and Coutellier L (2024) Kv3.1 voltage-gated potassium channels modulate anxiety-like behaviors in female mice. Neuroscience. 538: 68-79.
Woodward E*; Rangel-Barajas C*; Ringland A; Logrip M.L; Coutellier L. (2023) Sex-specific timelines for adaptations of prefrontal parvalbumin neurons in response to stress and changes in anxiety- and depressive-like behaviors. eNeuro
Woodward EM, Ringland A, Ackerman J, Coutellier L. (2022) Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice. Psychoneuroendocrinology. 148:105997.
Woodward EM, Coutellier L. (2021) Age- and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and neurodevelopmental disorders. Neurosci Biobehav Rev. 131:1228-1242.
Okine T, Shepard R, Lemanski E, Coutellier L. (2020) Sex differences in the sustained effects of ketamine on resilience to chronic stress. Frontiers in Behavioral Neuroscience. 14:581360. doi: 10.3389/fnbeh.2020.581360
Page CE, Shepard R, Heslin K, Coutellier L (2019) Prefrontal parvalbumin cells are sensitive to stress and mediate anxiety-related behaviors in female mice. Scientific Reports. 9(1):19772.
Page CE & Coutellier L (2019) Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition. Neuroscience & Biobehavioral Reviews. 105: 39-51.
Wellman C, Bangasser D, Bollinger J, Coutellier L, Logrip M, Moench K, Urban K. (2018) Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation. J. Neurosci. 38(44):9423-9432
Shepard R, Coutellier L. (2018) Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress. Molecular Neurobiology. 55(3): 2591-2602.
Shepard R, Page CE, Coutellier L (2016) Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: relevance for sex differences in stress-related disorders. Neuroscience. 332:1-12
Collaborations with other laboratories:
Coutellier L and Jeanneteau F (2022) The glucocorticoid footprint on the memory engram. Current Opinion in Endocrine and Metabolic Research. 25: 100378
Gu, Rice J, Coutellier L, JL Weiner (2019) Region-Specific Interneuron Demyelination and Heightened Anxiety Induced by Adolescent Binge Alcohol Drinking. Acta Neuropathologica Communications. In press.
Ardestani PM, Evans AK, Yi B, Nguyen T, Coutellier L, Shamloo M. (2017) Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer’s Disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology. 116:371-386
Coutellier L, Ardestani PM, Shamloo M. (2014) β1-adrenergic receptor activation enhances memory in Alzheimer’s disease model. Annals of Clinical and Translational Neurology. 1(5): 348-360
Publications before OSU:
Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA. (2013) A dramatic increase of C1q protein in the CNS during normal aging. Journal of Neuroscience. 33(33):13460-74
L. Coutellier (2013) Adaptive regulations in developing rodents following neonatal challenges. In G. Laviola and S. Macri. (Eds) (Mal)adaptive aspects of developmental stress. Springer Neurotoxicity Book Series.
L.Coutellier, Beraki S., Ardestani P.M., Saw N.L., Shamloo M. (2012) Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant for developmental disorders. Plos One. 7(9):e46604.
L.Coutellier (2012) Rodent models of early environment effects on offspring development and susceptibility to neurological diseases in adulthood. Translational Neuroscience. 3 (3): 258-262.
L.Coutellier, Logemann A., Rusnak, M and Usdin T. (2011) Maternal absence of the parathyroid-hormone 2 (PTH2) receptor affects postnatal pup development. Journal of Neuroendocrinology. 23(7): 612-619.
L.Coutellier and Usdin T. (2011) Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling. Behavioural Brain Research. 222(1): 265-269.
L.Coutellier, Logemann A. Kuo, J., Rusnak, M. and Usdin T. (2011) TIP39 modulates effects of novelty induced arousal on memory. Genes, Brain and Behavior, 10 (1): 90-99.
L.Coutellier and Würbel H. (2009) Early environmental cues affect object recognition memory in adult female but not male C57BL/6 mice. Behavioral Brain Research. 203: 312-315.
L.Coutellier, Friedrich, A.C., Failing, K., Marashi, V. and Würbel, H. (2009) Effects of variations in foraging demand on maternal behaviour and adult offspring anxiety and stress response in C57BL/6 mice. Behavioral Brain Research. 196 (2): 192-199.
L.Coutellier, Friedrich, A.C., Failing, K., Marashi, V. and Würbel, H. (2008) Effects of rat odour and shelter on maternal behaviour in C57BL/6 dams and on fear and stress responses in their adult offspring. Physiology and Behavior, 94: 393-404.
L.Coutellier, Friedrich, A.C., Failing, K. and Würbel, H. (2008) Variation of postnatal maternal environment in mice: effects on maternal behaviour and behavioural and endocrine responses in the adult offspring. Physiology and Behavior, 93: 395-407.