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Low-Resolution Mass Spectrometry
Waters Acquity UPLC with PDA and QDA Detectors
- Walk-up Access: OpenLynx software allows users to queue samples using pre-made methods and receive data by email when their run is completed.
- High Throughput: The UPLC front end allows for significantly shorter run times than equivalent HPLC methods.
- PDA UV-VIs Detector: Detect UV absorbance across a broad range of wavelengths. Find your compounds without needing to identify a specific lambda max.
- QDa Single Quadrupole MS: ESI ion source provides broad ionization capabilities. Quadrupole mass detector can observe ions ranging from 35 to 1250 m/z.
- Demonstrated proficiency on this instrument is required before users will be trained on more complex MS systems.
Thanks to Charles River for the donation of six Acquity Classic UPLC systems to the College. This is one of them.
Thermo Q-Exactive Orbitrap with Vanquish UPLC
- High Resolution: Up to 140,000 FWHM
- High Mass Accuracy: Better than 3ppm RMS with external calibration
- Sensitivity: Detects many compounds in the ng/mL range.
- Throughput: Pre-made four-minute runs for HRAM acquisitions.
- Versatile Analysis: Engage the built in quadrupole mass filter for targeted methods including data dependent analysis.
- Vanquish-H UPLC: Supports columns ranging from 5µm HPLC to the latest 1.5µm UPLC columns with a 20,000 psi pressure limit.
Thanks to the Divisions of Medicinal Chemistry and Pharmacognosy and to the Division of Pharmaceutics and Pharmacology for helping to fund the purchase of the Vanquish-H UHPLC.
Thanks to Dr. McElroy, Professor Pabla, and Professor Rakotondraibe for helping to purchase Compound Discoverer.
Quantitative Mass Spectrometry
Thermo TSQ Quantiva with Vanquish UPLC
- Ideal Method Transfer: Identical Vanquish-H UHPLC front ends allow for the simplest possible method transfer from the Q-Exactive. Discover with the Orbitrap, quantify with the Quantiva.
- Better Sensitivity: Significantly improved sensitivity compared with the Quattro Premier
- Automate Optimization: Once an ion beam is established, simply indicate the precursor ion and number of desired product ions and let the software optimize source and colision cell parameters for you.
Waters Quattro Premier with Acquity UPLC
- Method Development: Acquity UPLC allows for efficient method development cycles.
- AutoTune: Establish an ion beam and let the instrument software tune source and collision cell parameters for you.
- Wide Mass Range: Capable of handling masses from 2-3000m/z