We investigate the dynamic regulation of the actomyosin cytoskeleton in nonmuscle and muscle cells and their linkage to cell adhesion proteins at the plasma membrane. These processes are mediated by a complex network of structural and regulatory proteins. The dynamic interplay between cell adhesion proteins and the actomyosin cytoskeleton plays a vital role in regulating the assembly of cells into tissues and organs, controlling cell motility and migration, affecting cell shape, and coordinating various cellular signaling networks.
Our team employs multifaceted experimental approaches, including cryo-EM, X-ray crystallography, biochemistry, and cell biology, to elucidate the fundamental molecular mechanisms that regulate cell adhesion molecules and the actomyosin cytoskeleton in normal and diseased cells. We gain critical insights into the molecular mechanisms underlying various cytoskeletal protein-related diseases, including cancers, cardiovascular diseases, and neuromuscular disorders through structure-function studies. We believe these insights aid in designing novel rational therapeutics to improve patient outcomes. Thank you for your interest in our research.