Publications

  • Mediouni S, Chinthalapudi K, Ekka MK, Usui I, Jablonski JA, Clementz MA, Mousseau G, Nowak J, Macherla VR, Beverage JN, Esquenazi E, Baran P, Loret EP, Nettles K, Maiti S, Izard T, and Valente ST (2019) Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat. MBio.  5;10(1). pii: e02662-18
  • Chinthalapudi K, Rangarajan ES, and Izard T (2018). The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation. Proc Natl Acad Sci. 115(41):10339-10344 (highlighted in the Scientist magazine [https://www.the-scientist.com/image-of-the-day/image-of-the-day–keep-in-touch-64994])
  • Chinthalapudi K, Zheng J, Mandati V, Sharff A, Bricogne G, Griffin P, Kissil J, and Izard T (2018). Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2  Nature Commun. 9(1):1338
  • Chinthalapudi K*, Heissler SM*, Preller M, Manstein DJ, and Sellers JR (2017). Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C. eLife 2017;6:e32742 (*equal contributions) [https://doi.org/10.7554/eLife.32742]
  • Heissler SM, Chinthalapudi K, and Sellers JR (2017). Kinetic Signatures of Myosin-5B, the Motor Involved in Microvillus Inclusion Disease. J. Biol. Chem. 292(44):18372-18385
  • Chinthalapudi K, Rangarajan ES, Brown DT, and Izard T (2016). Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization. Proc Natl Acad Sci. 113(34):9539-44
  • Chinthalapudi K, Patil DN, Rangarajan ES, and Izard T (2015). Lipid-directed vinculin dimerization. Biochemistry (17):2758-68
  • Heissler SM, Chinthalapudi K, and Sellers JR (2015). Kinetic Characterization of the Sole Nonmuscle Myosin-2 from the Model Organism Drosophila Melanogaster. FASEB J. (4):1456-66
  • Chinthalapudi K, Rangarajan ES, Patil DN, George EM, Brown DT, and Izard T (2014). Lipid binding promotes oligomerization and focal adhesion activity of vinculin*. J Cell Biol. 207(5):643-56 *This study has been highlighted “In This Issue” of the journal.
  • Martin R, Risacher C, Barthel A, Jäger A, Schmidt AW, Richter S, Böhl M, Preller M, Chinthalapudi K, Manstein DJ, Gutzeit HO, and Knölker H-J (2014). Silver(I)-Catalyzed Route to Pyrroles: Synthesis of Halogenated Pseudilins as Allosteric Inhibitors for Myosin ATPase and X-ray Crystal Structures of the Protein–Inhibitor Complexes. Eur J Org Chem :4487-4505
  • Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker H-J, Coluccio LM, and Manstein DJ (2011). Mechanism and specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity. J. Biol. Chem. 286(34): 29700-29708
  • Preller M, Chinthalapudi K, Martin R, Knölker H-J, and Manstein DJ (2011). Inhibition of ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study. Med. Chem 54(11): 3675-3685
  • Polonais V, Javier Foth B, Chinthalapudi K, Marg JB, Manstein DJ, Soldati-Favre D, and Frénal K (2011). Unusual Anchor of a Motor complex (MyoD-MLC2) to the Plasma Membrane of Toxoplasma gondii. Traffic 12(3): 287-300
  • Chinthalapudi K, Kumar M, Kumar S, Jain R, Alam N, and Gourinath S (2008). Crystal Structure of Native O-acetyl-serine-sulfhydrylase from Entamoeba histolytica and its Complex with Cysteine: Structural Evidence for Cysteine Binding and Lack of Interactions with Serine Acetyl Transferase. Proteins 72(4): 1222-32
  • Chinthalapudi K, Jain R, Kashav T, Wadhwa D, Alam N, and Gourinath S (2007). Crystallization and Preliminary Crystallographic Analysis of Cysteine Synthase from Entamoeba histolytica    Acta Crystallogr. Sec. F. 63: 512-515