The Pharmacoanalytical Shared Resource (PhASR) within the OSUMC Comprehensive Cancer Center is seeking a research associate with analytical chemistry training and experience to develop and validate quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for pre-clinical and clinical studies for novel therapeutic agents per FDA guidelines. The two job postings related to this position can be found here https://wexnermedical.osu.edu/careers/current-openings/research/454144 and https://wexnermedical.osu.edu/careers/current-openings/research/454146. The successful candidate will plan experiments and prepare biological specimens by protein precipitation, phospholipid removal, liquid–liquid and solid phase extraction for LC, UV, fluorescence, ELISA, and MS/MS analyses, and for analysis by other methods, as appropriate. This position must be able to critically analyze and interpret original data and peer-reviewed literature in cooperation with other PhASR resources to plan future experiments. This position requires the ability to troubleshoot complex laboratory problems and provide solutions to achieve experimental objectives, as well as perform multiple tasks simultaneously and efficiently. Excellent written and verbal communication skills and attention to detail are required. This position prepares detailed project reports, SOPs, research progress reports for sponsors, creates figures and tables for manuscripts, attends and presents research results at laboratory meetings and seminars, and assists in the preparation of proposals for extramural funding. This position provides assistance in developing and managing project quotes and budgets for new and existing research projects. This successful applicant must monitor and enforce laboratory safety procedures to ensure compliance with OSHA regulations, and local, state and federal regulations, including proper disposal and maintenance of regulated materials
Preferred Skills: Working knowledge of Thermo XCalibur and/or Tracefinder software is a plus; Pharmacology experience to quantitatively characterize mechanisms of absorption, distribution, metabolism and excretion for novel drugs or drug candidates; Ability to apply pharmacokinetic/pharmacodynamic concepts and statistics to analyze, model and interpret resulting data; Experience developing and validating quantitative methods using LC, UV, fluorescence, ELISA, or other techniques.
Minimum Education Requirement: Bachelor’s Level Degree or Equivalent education and/or Experience in chemisty, pharmacology, biological/health science field or an equivalent combination of education and experience is required. Experience in the use of analytical assays to generate quantitative data is required. Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical, including a drug screen.