Cleveland Clinic Postdoctoral Position

Molecular Mechanisms and Translational Oncology

Do you have a background in molecular, biochemical or chemical mechanisms yet are interested in translational medicine?  Are you interested in taking your mechanistic findings rapidly to the bedside in a vibrant clinical research program?  If so, a postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic.

Our laboratory focuses on mechanistic discovery to understand the metabolic and molecular mechanisms of androgen synthesis and androgen receptor gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

1)      Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression

2)      Clinical validation in patients and clinical trials using innovative approaches

3)      Animal models of advanced prostate cancer for translational and therapeutic studies

4)      Identifying targets for the development of new pharmacologic therapies

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013;154:1074-84). We also recently discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015;523:347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016;533:547-51) and that these events are a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chem Biol. 2017;24:825-32) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018;128:3333-40). View a quick summary of these discoveries here:

https://www.youtube.com/watch?v=22dFzT4RFno

This position is ideal for an individual with a strong interest in rapid translation of basic mechanistic discoveries to the bedside as this is a principal goal of the Sharifi Laboratory. For example, we have shown that our discovery of a gain-of-function in a steroid-synthesizing enzyme is a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62).  We are currently evaluating this biomarker in an active clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries.

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at: http://www.lerner.ccf.org/cancerbio/sharifi/ and http://newsroom.clevelandclinic.org/?s=sharifi

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology; has the appropriate expertise in discovery of molecular, biochemical or chemical mechanisms; and is highly driven.  Outstanding verbal and communication skills are required. Interested candidates should send their CV and contact information for 3 references to:

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

Director, GU Malignancies Research Center

sharifn@ccf.org

 

 

 

 

Assistant Professor in Chemistry Position at CSU Monterey Bay

The Biology and Chemistry Department at California State University Monterey Bay (CSUMB) invites applications for a tenure-track position at the rank of Assistant Professor in Chemistry to begin in Fall 2020. All fields of Chemistry will be considered. CSUMB encourages applications from all underrepresented groups. For the first round of review, completed applications must be received by November 17, 2019; the position is open until filled. http://csumb.peopleadmin.com/postings/5463 .

Albert Schweitzer Fellowship Announcement

The Albert Schweitzer Fellowship (ASF) was founded in 1940 to support Dr. Albert Schweitzer’s hospital in Gabon, Africa. The U.S. Schweitzer Fellows Program was launched in 1991 with the mission to support and train emerging health-focused graduate and professional students in creating and carrying out service projects to address unmet community needs. At the end of their yearlong project, Fellows join the Schweitzer Fellows for Life alumni network, now more than 2,000 strong.

The Columbus-Athens Schweitzer Fellows Program is one of 13 ASF Programs located across the U.S. Since 2011, the Columbus-Athens Program has supported students who are dedicated to addressing the social determinants of health in underserved local communities, and whose example influences and inspires others.

Columbus-Athens Schweitzer Fellows are graduate or professional students whose fields of study or personal interests are relevant to the program’s mission. Fellows receive a stipend of $3,000 to carry out an April-to-April community service project of at least 200 service hours, of which at least 100 hours involve direct client contact. Fellows partner with an existing community agency in the Columbus or Athens area and have both an academic and a community-based mentor. Fellows attend an orientation and monthly meetings as well as participate in reflective leadership development programming. No academic credit is earned. Applications are due in February and more details on applying can be found in the flyer linked below.

ASF 2 page Flyer 2019-10-22 (1)

Research Associate/Research Specialist position at OSUMC CCC

The Pharmacoanalytical Shared Resource (PhASR) within the OSUMC Comprehensive Cancer Center is seeking a research associate with analytical chemistry training and experience to develop and validate quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for pre-clinical and clinical studies for novel therapeutic agents per FDA guidelines. The two job postings related to this position can be found here https://wexnermedical.osu.edu/careers/current-openings/research/454144 and https://wexnermedical.osu.edu/careers/current-openings/research/454146. The successful candidate will plan experiments and prepare biological specimens by protein precipitation, phospholipid removal, liquid–liquid and solid phase extraction for LC, UV, fluorescence, ELISA, and MS/MS analyses, and for analysis by other methods, as appropriate. This position must be able to critically analyze and interpret original data and peer-reviewed literature in cooperation with other PhASR resources to plan future experiments. This position requires the ability to troubleshoot complex laboratory problems and provide solutions to achieve experimental objectives, as well as perform multiple tasks simultaneously and efficiently. Excellent written and verbal communication skills and attention to detail are required. This position prepares detailed project reports, SOPs, research progress reports for sponsors, creates figures and tables for manuscripts, attends and presents research results at laboratory meetings and seminars, and assists in the preparation of proposals for extramural funding. This position provides assistance in developing and managing project quotes and budgets for new and existing research projects. This successful applicant must monitor and enforce laboratory safety procedures to ensure compliance with OSHA regulations, and local, state and federal regulations, including proper disposal and maintenance of regulated materials

Preferred Skills: Working knowledge of Thermo XCalibur and/or Tracefinder software is a plus; Pharmacology experience to quantitatively characterize mechanisms of absorption, distribution, metabolism and excretion for novel drugs or drug candidates; Ability to apply pharmacokinetic/pharmacodynamic concepts and statistics to analyze, model and interpret resulting data; Experience developing and validating quantitative methods using LC, UV, fluorescence, ELISA, or other techniques.

Minimum Education Requirement: Bachelor’s Level Degree or Equivalent education and/or Experience in chemisty, pharmacology, biological/health science field or an equivalent combination of education and experience is required. Experience in the use of analytical assays to generate quantitative data is required. Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical, including a drug screen.

CSULA seeking Analytical Chemistry Assistant Professor for Fall 2020

The Department of Chemistry & Biochemistry at California State University, Los Angeles is again recruiting for a faculty position in Analytical Chemistry at the rank of Assistant Professor. The position will begin in August, 2020 with the Fall academic term. The full position announcement can be found on the University’s website at:

http://www.calstatela.edu/2020/college-natural-social-sciences/nss-cb-ttf

CSULA is a comprehensive urban university located east of Downtown Los Angeles with an enrollment of approximately 28,000 students representing one of the most diverse student populations in the country.  The Department of Chemistry & Biochemistry offers B.S. degrees in Chemistry and Biochemistry and an M.S. degree in Chemistry with the optional emphasis in Biochemistry.  The Department hosts approximately 800 undergraduate majors and 50 Master’s students.  The Department has a strong tradition and commitment to research success involving undergraduate and Master’s students, and its 17 full-time faculty are active in teaching and research with an ethnically and socioeconomically diverse student population.  We invite interested candidates to apply for this position in Analytical Chemistry by the Dec. 1, 2019 deadline.

Tenure track faculty position at Virginia Tech

The Department of Chemistry at Virginia Tech invites applications for a tenure-track faculty position at the assistant professor level in
any area of chemistry, including analytical, biological, environmental, inorganic, materials, organic, physical, polymer, and
theoretical/computational chemistry, with an intended start date of fall 2020.

A Ph.D. in Chemistry or a closely related field is required; the degree is required at the time of appointment. The successful candidate
must establish an internationally recognized research program and be an effective teacher in graduate and undergraduate courses.
Applicants must submit application materials online at jobs.vt.edu in response to job number 511300. Application materials include a
curriculum vita, a description of research plans (not to exceed five pages), a statement of teaching philosophy and plans (not to exceed
two pages), and three letters of recommendation. Review of applications will begin November 1, 2019 and will continue until the
position is filled.

For any questions specifically related to the position, please contact Amanda Morris, Search Committee Chair, at chemsearch@vt.edu.

For further information about the position and the Department of Chemistry, please visit www.chem.vt.edu.

Virginia Tech does not discriminate against employees, students, or applicants on the basis of age, color, disability, sex (including pregnancy), gender, gender identity, gender
expression, genetic information, national origin, political affiliation, race, religion, sexual orientation, or veteran status, or otherwise discriminate against employees or
applicants who inquire about, discuss, or disclose their compensation or the compensation of other employees or applicants, or on any other basis protected by law.

Boise State University Chemistry Faculty Search

The Department of Chemistry and Biochemistry at Boise State University is looking to hire two new Faculty. The first position is for Tenure-Track Assistant Professor in Analytical Chemistry. The second position is for a Clinical Assistant Professor. See the attached job listings to apply. Please feel free to share the attachments.

ClinicalAssistantProfessor_Fall2020_Search_final

Analytical Chemistry Faculty Job Announcement 2019-with link

Tenure-Track Faculty Positions at UNT

The Chemistry Department at the University of North Texas is seeking to fill two tenure-track faculty positions at the Assistant Professor level:  one in Synthetic Organic Chemistry, and one in Chemistry Education.

I would appreciate your assistance in forwarding this email to any faculty in your department who might have students or postdoctoral scholars seeking faculty positions in these two areas.  Applications may be submitted by visiting https://facultyjobs.unt.edu and searching for positions in the Chemistry department.  Links to the specific job postings can be found here for Synthetic Organic Chemistry and Chemistry Education (please click each link twice to reach the application page). You are also welcome to post or forward the attached flyers.

Both positions will contribute to strategic growth in the UNT Chemistry Department.  The Organic Chemistry faculty member is expected interface with and/or contribute to a growing emphasis on chemical biology, and will have joint membership in the BioDiscovery Institute (http://bdi.unt.edu), a center of excellence focused on fundamental research in biobased products and materials.  The Chemistry Education faculty member will play a key role in revitalizing UNT’s doctoral program in Chemistry Education, and will have opportunities to align their research with university-wide initiatives in effective online and hybrid instruction, virtual reality, and other digital learning technologies.

The University of North Texas (UNT) is a Carnegie R1 research university with a diverse population of 39,000 students.  UNT is located in Denton, a cultural hot spot on the northern edge of the Dallas-Fort Worth Metroplex, one of the fastest growing metropolitan areas in the country.  The UNT Chemistry Department is entering a growth phase, with plans to hire an endowed Welch Chair in Chemistry and up to 10 additional tenure-track faculty over the next five years.  Our department has a strong culture of interdisciplinary collaboration, with specific strengths in computational chemistry, photochemistry, and materials chemistry.  New faculty will have access to our world-class High-Performance Computing infrastructure and will have opportunities to interface with growing emphasis areas in chemical biology and interdisciplinary energy science.

UNT Organic Chemistry Position_Flyer

UNT Chem Ed Assistant Professor_Flyer