EPA has an exciting GRIP opportunity in the Research Triangle Park, N.C. Students will be involved in exciting projects that involve interpretation of large gene expression datasets encompassing profiles from thousands of chemicals using novel approaches that allow establishing linkages between chemical exposure, modulation of transcription factors, and adverse outcomes.
Students will gain experience in a government lab solving problems in environmental health, learn to utilize the data in the world’s largest database of genomic data (Illumina’s BaseSpace Correlation Engine), and gain experience in carrying out and validating Crispr-Cas9 knockouts in human cell lines. Students will co-author papers with Dr. Corton and his team.
A link to a more complete project description is found here: https://www.epa.gov/research-grants/using-gene-expression-predict-toxicity-caused-environmental-chemicals. A link to Dr. Corton’s publications may be found at: https://www.ncbi.nlm.nih.gov/pubmed/?term=corton+jc.
Students are encouraged to contact Dr. Chris Corton directly to discuss this opportunity. His contact information is:
Chris Corton, Ph.D., Senior Research Biologist
Systems Biology Branch
Integrated Systems Toxicology Division (ISTD)
National Health and Environmental Effects Research Lab
US Environmental Protection Agency
109 T.W. Alexander Dr.
Research Triangle Park, NC 27711