Cruciferous Vegetables, Glucosinolates, and Isothiocyanates

Research Publications

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 Abbaoui B, Lucas CR, Riedl KM, Clinton SK, Mortazavi A. Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention,  Molecular Nutrition & Food Research, August 2018

Besma Abbaoui, Kelly H. Telu, Christopher R. Lucas, Jennifer M. Thomas-Ahner , Steven J. Schwartz , Steven K. Clinton, Michael A. Freitas,  Amir Mortazavi.  2017. The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancerJournal of Proteomics. Volume 156, 6 March 2017, Pages 94–103.

Bricker GV, Riedl KM, Ralston RA, Tober KL, Oberyszyn TM, Schwartz SJ. 2014. Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane. Mol Nutr Food Res. 58(10):1991-2000.

Liu AG, Juvik JA, Jeffery EH, Berman-Booty LD, Clinton SK, Erdman JW. 2014. Enhancement of broccoli indole glucosinolates by methyl jasmonate treatment and effects on prostate carcinogenesis. J Med Food. 17(11):1177-82.

Li Y, Zhang T, Li X, Zou P, Schwartz SJ, Sun D. 2013. Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation. Mol Nutr Food Res. 57(12):2128-36.

Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A. 2012. Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: Characterization, metabolism, and interconversion. Mol Nutr Food Res. 56(11):1-13.

Li Y, Karagoz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rudiger SG, Sun D. 2012. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 23(12):1617-26.

Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. 2011. Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. J Agric Food Chem. 59(20):10955-10963.

Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E. 2011. Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. Pharmacol Res. 64(5):456-463.

Li Y, Zhang T, Schwartz SJ, Sun D. 2011. Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr Cancer. 63(7):1151-1159.

Li YY, Zhang T, Korkaya H, Liu SL, Lee HF, Newman B, Yu YK, Clouthier SG, Schwartz SJ, Wicha MS, Sun DX. 2010. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research. 16(9):2580-2590.

Mortazavi A, Ralston RA, Grainger EM, Schwartz SJ, Clinton SK. 2008. Cruciferous vegetables and bladder cancer. In: Botanical medicine in clinical practice. Eds. Watson RR, Preedy VR. CAB International, Wallingford, United Kingdom. 278.

Reen RK, Dombkowski AA, Kresty LA, Cukovic D, Mele JM, Salagrama S, Nines R, Stoner GD. Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 2007 Jul;67(13):6484-92.

Canene-Adams K, Jeffery EH, Clinton SK, Erdman JW, Jr. Mechanisms behind anti-tumor activity in Dunning R3327-H prostate adenocarcinomas as a result of tomato and broccoli consumption [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A59.

Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW, Jr. Combinations of tomato and broccoli enhance antitumor activity in Dunning R3327-H prostate adenocarcinomas. Cancer Res 2007 Jan;67(2):836-43.

Canene-Adams K, Clinton SK, Wang SH, Erdman JW,Jr. Effects of diets containing lycopene, tomato, and/or broccoli upon tumor growth and biomarkers in the Dunning R3327-H prostate adenocarcinoma model [Abstract]. In: FASEB J; Mar; Bethesda, MD: Amer Society Nutritional Science; 2006. p. A150.

Tian Q, Rosselot RA, Schwartz SJ. Quantitative determination of intact glucosinolates in broccoli, broccoli sprouts, Brussels sprouts, and cauliflower by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Anal Biochem 2005 Aug;343(1):93-9.

Canene-Adams K, Clinton SK, Erdman JW,Jr. Effects of dietary lycopene, tomato, and broccoli powders on the growth of Dunning R3327-H prostatic adenocarcinoma tumors [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2005. p. A79.

Hudson TS, Stoner GD, Morse MA, Young H, Mallery SR. Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. Toxicol Lett 2005 Mar;155(3):427-36.