Berries, Anthocyanins, and Resveratrol

Research Publications

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Gu J, Thomas-Ahner JM, Riedl KMBailey MT, Vodovotz Y, Schwartz SJ, Clinton SKDietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice.  Molecular Nutrition & Food Research, February 2019

Cotten BM, Diamond SA, Banh T, Hsiao YH, Cole RM, Li J, Simons CT, Bruno RS, Belury MA, Vodovotz YRaspberry ketone fails to reduce adiposity beyond decreasing food intake in C57BL/6 mice fed a high-fat diet. Food & Function, April 2017

Roberts KM, Grainger EM, Thomas-Ahner JM, Hinton A, Gu J, Riedl K, Vodovotz Y, Abaza R, Schwartz SJ, Clinton SK. 2016. Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men. Mol Nutr Food Res. Epub ahead of print.

Shi N, Riedl KM, Schwartz SJ, Zhang X, Clinton SK, Chen T. 2016. Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats. J Funct Foods, 27: 84–94.

Ahmadiani N, Robbins RJ, Collins TM, Giusti MM. 2016. Molar absorptivity (ε) and spectral characteristics of cyanidin-based anthocyanins from red cabbage. Food Chem. 197(Pt A):900-6.

Knobloch TJ, Uhrig LK, Pearl DK, Casto BC, Warner BM, Clinton SK, Sardo-Molmenti CL, Ferguson JM, Daly BT, Riedl K, Schwartz SJ, Vodovotz Y, Buchta AJ Sr, Schuller DE, Ozer E, Agrawal A, Weghorst CM. 2016. Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Cancer Prev Res (Phila). 9(2):159-71.

Chatthongpisut R, Schwartz SJ, Yongsawatdigul J. 2015. Antioxidant activities and antiproliferative activity of Thai purple rice cooked by various methods on human colon cancer cells. Food Chem. 188: 99-105.

Wallace TC, Giusti MM. 2015. Anthocyanins. Adv Nutr. 6(5):620-2.

Shi N, Clinton S, Liu Z, Wang Y, Riedl K, Schwartz SJ, Zhang X, Pan Z, Chen T. 2015. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients. 7(3): 1696-1715.

Gu J, Ahn-Jarvis JH, Vodovotz Y. 2015. Development and characterization of different black raspberry confection matrices designed for delivery of phytochemicals. J Food Sci. 80(3): 610-618.

Garzon GA, Manns D, Padilla-Zakour O, Riedl KM, Schwartz SJ. 2014. Identification of phenolic compounds in petals of nasturtium flowers (Tropaeolum majus) by high-performance liquid chromatography coupled to mass spectrometry and determination of oxygen radical absorbance capacity (ORAC). J Agric Food Chem. 63(6):1803-1811.

Shi N, Clinton S, Liu Z, Wang Y, Riedl K, Schwartz S, Zhang X, Pan Z, Chen T. 2015. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients. 7(3):1696–1715.

Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB. 2014. Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother. 63(9):889-900.

Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CM. Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014.118(6):674–83.

Kovinich N, Kayanja G, Chanoca A, Riedl K, Otegui MS, Grotewold E. 2014. Not all anthocyanins are born equal: distinct patterns induced by stress in Arabidopsis. Planta. 240(5):931–40.

Joehlin-Price AS, Elkins CT, Stephens JA, Cohn DE, Knobloch TJ, Weghorst CM, Suarez AA. 2014. Comprehensive evaluation of caspase-14 in vulvar neoplasia: An opportunity for treatment with black raspberry extract. Gynecol Oncol. 135(3):503–9.

Kamonpatana K, Failla ML, Kumar PS, Giusti MM. 2014. Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa. J Agric Food Chem. 62(29):6903-10.

Gu J, Ahn-Jarvis J, Riedl KM, Schwartz SJ, Clinton SK, Vodovotz Y. 2014. Characterization of black raspberry functional food products for cancer prevention human clinical trials. J Agric Food Chem. 62(18):3997-4006.

Fisher EL, Ahn-Jarvis J, Gu J, Weghorst CM, Vodovotz Y. 2014. Assessment of physicochemical properties, dissolution kinetics and storage stability of a novel strawberry confection designed for delivery of chemopreventive agents. Food Struct. 1(2):171–81.

Paudel L, Wyzgoski FJ, Giusti MM, Johnson JL, Rinaldi PL, Scheerens JC, Chanon AM, Bomser JA, Miller AR, Hardy JK, Reese RN. 2014. NMR-based metabolomic investigation of bioactivity of chemical constituents in black taspberry (Rubus occidentalis L.) fruit extracts. J Agric Food Chem. 62(8):1989-98.

Paudel L, Wyzgoski FJ, Scheerens JC, Chanon AM, Reese RN, Smiljanic D, Wesdemiotis C, Blakeslee JJ, Riedl KM, Rinaldi PL. 2013. Nonanthocyanin secondary metabolites of black raspberry (Rubus occidentalis L.) fruits: identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS analyses. J Agric Food Chem. 61:12032–43.

Giusti MM, Wallace TC, editors. 2013. Anthocyanins in Health and Disease. Boca Raton, FL: CRC Press; p. 368.

Chen T, Yan F, Qian J, Guo M, Zhang H, Tang X, Chen F, Stoner GD, Wang X. 2012. Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus. Cancer Prev Res. (Phila). 5(1):41–50.

Kamonpatana K, Giusti MM, Chitchumroonchokchai C, Moreno Cruz M, Riedl KM, Kumar P, Failla ML. 2012. Susceptibility of anthocyanins to ex vivo degradation in human saliva. Food Chem. 135(2):738-747.

Zhang ZX, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CM. 2011. A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecologic Oncology. 123(2):401-406.

Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J, 3rd, Yang GY, Stoner G. 2011. Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: A phase I pilot study. Clin Cancer Res. 17(3):598-610.

Johnson JL, Bomser JA, Scheerens JC, Giusti MM. 2011. Effect of black raspberry (Rubus occidentalis l.) extract variation conditioned by cultivar, production site, and fruit maturity stage on colon cancer cell proliferation. J Agric Food Chem. 59(5):1638-1645.

He J, Giusti MM. 2011. High-purity isolation of anthocyanins mixtures from fruits and vegetables–a novel solid-phase extraction method using mixed mode cation-exchange chromatography. J Chromatogr A. 1218(44):7914-7922.

Del Carpio Jiménez C, Serrano Flores C, He J, Tian Q, Schwartz SJ, Giusti MM. 2011. Characterisation and preliminary bioactivity determination of Berberis boliviana Lechler fruit anthocyanins. Food Chem. 128(3):717-724.

Estupinan DC, Schwartz SJ, Garzon GA. 2011. Antioxidant activity, total phenolics content, anthocyanin, and color stability of isotonic model beverages colored with andes berry (Rubus glaucus benth) anthocyanin powder. J Food Sci. 76(1):S26-34-S26-34.

Wallace TC, Giusti MM. 2010. Extraction and normal-phase HPLC-fluorescence-electrospray MS characterization and quantification of procyanidins in cranberry extracts. J Food Sci. 75(8):C690-696.

Wallace TC, Giusti MM. 2010. Evaluation of parameters that affect the 4-dimethylaminocinnamaldehyde assay for flavanols and proanthocyanidins. J Food Sci. 75(7):C619-625.

Pourcel L, Irani NG, Lu YH, Riedl K, Schwartz S, Grotewold E. 2010. The formation of anthocyanic vacuolar inclusions in Arabidopsis thaliana and implications for the sequestration of anthocyanin pigments. Molecular Plant. 3(1):78-90.

Knobloch TJ, Casto BC, Agrawal A, Clinton SK, Weghorst CM. 2010. Cancer prevention in populations high at-risk for the development of oral cancer: Clinical trials with black raspberries. In: Berries and cancer prevention. Eds. Stoner GD, Seeram N. Springer, New York, NY. 259-280.

He J, Giusti MM. 2010. Anthocyanins: Natural colorants with health-promoting properties. Annu Rev Food Sci Technol. 1:163-187.

Garzon GA, Narvaez CE, Riedl KM, Schwartz SJ. 2010. Chemical composition, anthocyanins, non-anthocyanin phenolics and antioxidant activity of wild bilberry (Vaccinium meridionale swartz) from Colombia. Food Chemistry. 122(4):980-986.

Scheerens JC. 2010. Grapes in the western heartland and great plains: Regional challenges, innovative solutions and unique products. HortScience. Vol 44. 2009:995-995.

Garzon GA, Narvaez CE, Riedl KM, Schwartz SJ. 2010. Chemical composition, anthocyanins, non-anthocyanin phenolics and antioxidant activity of wild bilberry (Vaccinium meridionale Swartz) from Colombia. Food Chemistry. 122(4):980-986.

He JA, Giusti MM. 2010. Anthocyanins: Natural Colorants with Health-Promoting Properties. Annual Review of Food Science and Technology, Vol 1. 1:163-186.

Pourcel L, Irani NG, Lu YH, Riedl K, Schwartz S, Grotewold E. 2010. The Formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and Implications for the Sequestration of Anthocyanin Pigments. Molecular Plant. 3(1):78-90.

Casto BC, Knobloch TJ, Weghorst CM. 2010. Inhibition of oral cancer in animal models by berries. In: Berries and cancer prevention. Eds. Stoner GD, Seeram N. Springer, New York, NY. 189-207.

Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD. 2009. Black Raspberry Components Inhibit Proliferation, Induce Apoptosis, and Modulate Gene Expression in Rat Esophageal Epithelial Cells. Nutrition and Cancer-an International Journal. 61(6):816-826.

Duncan FJ, Martin JR, Wulff BC, Stoner GD, Tober KL, Oberyszyn TM, Kusewitt DF, Van Buskirk AM. 2009. Topical Treatment with Black Raspberry Extract Reduces Cutaneous UVB-Induced Carcinogenesis and Inflammation. Cancer Prevention Research. 2(7):665-672.

He J, Wallace TC, Keatley KE, Failla ML, Giusti MM. 2009. Stability of Black Raspberry Anthocyanins in the Digestive Tract Lumen and Transport Efficiency into Gastric and Small Intestinal Tissues in the Rat. J Agric Food Chem. 57(8):3141-3148.

Garzon GA, Riedl KM, Schwartz SJ. 2009. Determination of Anthocyanins, Total Phenolic Content, and Antioxidant Activity in Andes Berry (Rubus glaucus Benth). J. Food Sci. 74(3):C227-C232.

Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr Cancer. 2008;60 Suppl 1:61-69.

Giusti MM, Wrolstad RE. 2008. Color quality of maraschino cherries. In: Color quality of fresh and processed fruits and vegetables. Eds. Wrolstad RE, Culbert. ACS Publications.

Ozgen M, Wyzgoskiz FJ, Tulio AZ, Gazula A, Miller AR, Scheerens JC, Reese RN, Wright SR. Antioxidant capacity and phenolic antioxidants of midwestern black raspberries grown for direct markets are influenced by production site. HortScience. 2008 Dec;43:2039-47.

Shiroma-Kian C, Tay D, Manrique I, Giusti MM, Rodriguez-Saona LE. Improving the screening process for the selection of potato breeding lines with enhanced polyphenolics content. J Agric Food Chem. 2008 Nov; 56(21): 9835-42.

Jing P, Bomser JA, Schwartz SJ, He J, Magnuson BA, Giusti MM. Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. J Agric Food Chem. 2008 Oct; 56(20):9391-98.

Grotewold E, Davies K. Trafficking and sequestration of anthocyanins. Nat Product Comm 2008 Sep;3(8):1251-8.

Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF. Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res. 2008 Aug;68(15):6460-6467.

Mallery SR, Zwick JC, Pei P, Tong M, Larsen PE, Shumway BS, Lu B, Fields HW, Mumper RJ, Stoner GD. Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res. 2008 Jun;68(12):4945-4957.

Wallace TC, Giusti MM. Determination of color, pigment, and phenolic stability in yogurt systems colored with nonacylated anthocyanins from Berberis boliviana L. as compared to other natural/synthetic colorants. J Food Sci 2008 May;73(4):C241-8.

Shumway BS, Kresty LA, Larsen PE, Zwick JC, Lu B, Fields HW, Mumper RJ, Stoner GD, Mallery SR. Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin.Cancer Res. Apr 15 2008;14(8):2421-2430.

Tulio AZ, Reese RN, Wyzgoski FJ, Rinaldi PL, Fu R, Scheerens JC, Miller AR. Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. J Agric Food Chem 2008 Mar;56(6):1880-8.

Barden CA, Chandler HL, Lu P, Bomser JA, Colitz CM. Effect of grape polyphenols on oxidative stress in canine lens epithelial cells. Am J Vet Res 2008 Jan;69(1):94-100.

Li J, Zhang D, Stoner GD, Huang C. Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog 2008 Apr;47(4):286-94.

Poustka F, Irani NG, Feller A, Lu Y, Pourcel L, Frame K, Grotewold E. A trafficking pathway for anthocyanins overlaps with the endoplasmic reticulum-to-vacuole protein-sorting route in arabidopsis and contributes to the formation of vacuolar inclusions. Plant Physiol 2007 Dec;145(4):1323-35.

Chen T, Rose ME, Hwang H, Nines RG, Stoner GD. Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. Carcinogenesis 2006 Nov;27(11):2301-7.

Jing P, Noriega V, Schwartz SJ, Giusti MM. Effects of growing conditions on purple corncob (Zea mays L.) anthocyanins. J Agric Food Chem 2007 Oct;55(21):8625-9.

Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF. Cancer prevention with freeze-dried berries and berry components. Semin Cancer Biol 2007 Oct;17(5):403-10.

Jing P, Giusti MM. Effects of extraction conditions on improving the yield and quality of an anthocyanin-rich purple corn (Zea mays L.) color extract. J Food Sci 2007 Sep;72(7):C363-8.

Prajitna A, Dami I, Steiner TE, Ferree DC, Scheerens JC, Schwartz SJ. Influence of cluster thinning on phenolic composition, resveratrol, and antioxidant capacity in chambourcin wine. Amer J Enol Vit 2007 Sep;58(3):346-50.

Stoner GD, Aziz RM. Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries. Acta Pharmacol Sin 2007 Sep;28(9):1422-8.

Giusti MM, Jing P. 2007. Analysis of pigments and colorants: Analysis of anthocyanins. In: Food colorants: Chemical and functional properties. Ed. Socaciu C. CRC Press, Boca Raton, FL.

Giusti MM, Jing P. 2007. Berry pigments. In: Berry fruit: Value-added products for health promotion. Ed. Zhao Y. CRC Press, Boca Raton, FL.

Huang C, Zhang D, Li J, Tong Q, Stoner GD. Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries. Nutr Cancer 2007 Jul;58(2):205-12.

Tulio AZ, Reese RN, Ozgen M, Miller AR, Scheerens JC. Cyanidin 3-rutinoside levels and antioxidant properties in black raspberries as impacted by fruit maturation and storage temperature [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2007. p. 985.

Keatley K, Klein RD, Failla ML, He J, Giusti MM, Kresty LA. Inhibition of proliferation of human bladder epithelial cancer cell lines by anthocyanin-rich fraction from black raspberries [Abstract]. In: IFT Annual Mtg Tech Program; Jul; Chicago, IL: Institute of Food Technologists; 2007. p. 146-09.

Singletary KW, Jung KJ, Giusti MM. Anthocyanin-rich grape extract blocks breast cell DNA damage. J Medicinal Foods 2007 Jun;10(2):244-51.

Stanton MA, Scheerens JC, Funt RC, Clark JR. Floral competence of primocane-fruiting blackberries prime-jan and prime-jan grown at three temperature regimen. Hort Rev 2007 Jun;42(3):508-13.

He J, Rodriguez-Saona LE, Giusti MM. Mid-infrared spectroscopy for juice authentication – rapid differentiation of commercial juices. J Agric Food Chem 2007 May;55(11):4443-52.

Cheng LQ, Xu YJ, Grotewold E, Jin Z, Wu FY, Fu CX, Zhao D. Characterization of anthocyanidin synthase (ANS) gene and anthocyanidin in rare medicinal plant-Saussurea medusa. Plant Cell Tiss Organ Cult 2007 Apr;89(1):63-73.

Gazula A, Kleinhenz M, Scheerens JC, Ling PP. Anthocyanin levels in nine lettuce (Lactuca sativa) cultivars: Influence of planting date and relations among analytic, instrumented, and visual assessments of color. Hortscience 2007 Apr;42(2):232-8.

Mallery SR, Stoner GD, Larsen PE, Fields HW, Rodrigo KA, Schwartz SJ, Tian Q, Dai J, Mumper RJ. Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention. Pharm Res 2007 Apr;24(4):728-37.

Netzel M, Netzel G, Tian Q, Schwartz SJ, Konczak I. Sources of antioxidant activity in Australian native fruits: identification and quantification of anthocyanins. J Agric Food Chem 2006 Dec;54(26):9820-6.

Stoner GD. Prevention of gastrointestinal tract cancers with lyophilized berries [Abstract]. In: Toxicologic Pathology; Dec; Philadelphia, PA: Taylor and Francis; 2006. p. 996-7.

Prajitna A, Dami I, Steiner TE, Scheerens JC, Miller AR, Schwartz SJ. Influence of cluster thinning on polyphenolic and antioxidant of chambourcin fruit and wine [Abstract]. In: Amer J Enol Vit, Davis, CA: Amer Soc Enology Viticulture; 2006. p. 529.

Chirinos R, Campos D, Betalleluz I, Giusti MM, Schwartz SJ, Tian Q, Pedreschi R, Larondelle Y. High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum Ruiz and Pavon) and their contribution to the overall antioxidant activity. J Agric Food Chem 2006 Sep;54(19):7089-97.

Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis 2006 Aug;27(8):1617-26.

Gazula A, Kleinhenz M, Ling PP, Scheerens JC. Planting date effects on anthocyanin concentrations in nine lettuce (Lactuca sativa) varieties and relationships among anthocyanin levels and instrumented and visual assessments of color [Abstract]. In: Hortscience Jul; Alexandria, VA: Amer Soc Horticultural Science; 2006. p. 1000.

King RE, Bomser JA, Min DB. Bioactivity of resveratrol. Comp Rev Food Sci Food Safety 2006 Jul;5(3):65-70.

Ozgen M, Tulio AZ, Chanon AM, Janakiraman N, Reese RN, Miller AR, Scheerens JC. Phytonutrient accumulation and antioxidant capacity at eight developmental stages of black raspberry fruit [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2006. p. 1082.

Ozgen M, Tulio AZ, Chanon AM, Janakiraman N, Reese RN, Miller AR, Scheerens JC. Variation in cornelian cherry phytonutrient capacity [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2006. p. 1038-9.

Tulio AZ, Chanon AM, Janakiraman N, Ozgen M, Stoner GD, Reese RN, Miller AR, Scheerens JC. Effects of storage temperatures on the antioxidant capacity and anthocyanin contents of black raspberries [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2006. p. 1043.

Wyzgoski FJ, Miller AR, Scheerens JC, Rinaldi PL, Bishop BL, Reese RN, Ozgen M, Tulio AZ, Giusti MM, Bomser JA. A nuclear magnetic resonance spectroscopy-based approach to profile biologically active plant metabolites using black raspberry inhibition of colon cancer cell proliferation as a model system [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2006. p. 1000.

He J, Magnuson BA, Lala G, Tian Q, Schwartz SJ, Giusti MM. Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation. Nutr Cancer 2006 Apr;54(1):3-12.

Lala G, Malik M, Zhao C, He J, Kwon Y, Giusti MM, Magnuson BA. Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer 2006 Apr;54(1):84-93.

Rodrigo KA, Rawal Y, Renner RJ, Schwartz SJ, Tian Q, Larsen PE, Mallery SR. Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 2006 Apr;54(1):58-68.

Chen T, Hwang H, Rose ME, Nines RG, Stoner GD. Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res 2006 Mar;66(5):2853-9.

Tian Q, Giusti MM, Stoner GD, Schwartz SJ. Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J Agric Food Chem 2006 Feb;54(4):1467-72.

Tian Q, Giusti MM, Stoner GD, Schwartz SJ. Characterization of a new anthocyanin in black raspberries (Rubus occidentalis) by liquid chromatography electrospray ionization tandem mass spectrometry. Food Chem 2006 Feb;94(3):465-8.

Huang C, Li J, Song L, Zhang D, Tong Q, Ding M, Bowman L, Aziz R, Stoner GD. Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res 2006 Jan;66(1):581-7.

Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, Fromkes JJ. Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett’s esophagus patients. Nutr Cancer 2006 Jan;54(1):148-56.

Lu H, Li J, Zhang D, Stoner GD, Huang C. Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes. Nutr Cancer 2006 Jan;54(1):69-78.

Reen RK, Nines R, Stoner GD. Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats. Nutr Cancer 2006 Jan;54(1):47-57.

Stoner GD, Chen T, Kresty LA, Aziz R, Reinemann T, Nines R. Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer 2006 Jan;54(1):33-46.

Stoner GD. Prevention of aerodigestive tract cancers with berries [Abstract]. In: J Nutr; Dec; Bethesda, MD: Amer Society Nutritional Science; 2005. p. 3033S.

Jing P, Giusti MM. Characterization of anthocyanin-rich waste from purple corncobs (Zea mays L.) and its application to color milk. J Agric Food Chem 2005 Nov;53(22):8775-81.

Kresty LA, Stoner GD, Frankel WL, Hammond CD, Baird ME, Mele JM, Fromkes JJ. Interim results of a pilot study evaluating the chemopreventive potential of lyophilized black raspberries in patients with Barretts esophagus [Abstract]. In: Cancer Epidemiol;Biomarkers Prev; Nov; Philadelphia, PA: Amer Assoc Cancer Research; 2005. p. 2734S.

Knobloch TJ, Casto BC, Kresty LA, Stoner GD, D’Ambrosio SM, Mallery SR, Schut HA, Kraley C, Peark DK, Pearson E, Sardo CL, Weghorst CM. Bench to bedside: Chemoprevention of oral cancer by black raspberries [Abstract]. In: Cancer Epidemiol;Biomarkers Prev; Nov; Philadelphia, PA: Amer Assoc Cancer Research; 2005. p. 2751S.

Zikri NN, Hecht SS, Carmella SG, Auer H, Chen T, Stoner GD. Effects of black raspberry components on growth and gene expression in rat esophageal epithelial cells [Abstract]. In: Cancer Epidemiol;Biomarkers Prev; Nov; Philadelphia, PA: Amer Assoc Cancer Research; 2005. p. 2751S.

Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol 2005 Oct;45(10):1153-64.

Tian Q, Giusti MM, Stoner GD, Schwartz SJ. Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring. J Chromatogr A 2005 Oct;1091(1-2):72-82.

Tian Q, Konczak I, Schwartz SJ. Probing anthocyanin profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J Agric Food Chem 2005 Aug;53(16):6503-9.

Tulio AZ, Ozgen M, Reese RN, Schwartz SJ, Tian Q, Stoner GD. Anthocyanins as primary antioxidants in black raspberries [Abstract]. In: Hortscience; Jul; Alexandria, VA: Amer Soc Horticultural Science; 2005; p. 1091.

He J, Magnuson BA, Giusti MM. Analysis of anthocyanins in rat intestinal contents–impact of anthocyanin chemical structure on fecal excretion. J Agric Food Chem 2005 Apr;53(8):2859-66.

Han C, Ding H, Casto B, Stoner GD, D’Ambrosio SM. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 2005 Mar;51(2):207-17.

King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005;151(2):143-9.

Tian Q, Aziz RM, Stoner GD, Schwartz SJ. Anthocyanin determination in black raspberry (Rubus occidentalis) and biological specimens using liquid chromatography-electrospray ionization tandem mass spectrometry. J Food Sci 2005 Jan;70(1):C43-7.