Mechanistic Research and Preclinical Studies

Research Publications

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Divya Nedungadi, Nathan Ryan, Kelvin Anderson, Felipe F Lamenza, Pete P Jordanides, Michael J Swingler, Liva Rakotondraibe, Kenneth M Riedl, Hans Iwenofu, and Steve Oghumu (2022). Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. Carcinogenesis, 43 (1).

Deena B. Snoke, Yuko Nishikawa, Rachel M. Cole, Ai Ni, Austin Angelotti, Yael Vodovotz, and Martha A. Belury (2021). Dietary Naringenin Preserves Insulin Sensitivity and Grip Strength and Attenuates Inflammation but Accelerates Weight Loss in a Mouse Model of Cancer Cachexia. Molecular Nutrition and Food Research, 65 (22).

Diana Rocha-Mendoza, Erica Kosmerl, Abigail Krentz, Lin Zhang, Shivani Badiger, Gonzalo Miyagusuku-Cruzado, Alba Mayta-Apaza, Monica Giusti, Rafael Jiménez-Flores, and Israel García-Cano (2021). Invited review: Acid whey trends and health benefits. Journal of Dairy Science, 204 (2).

Emily B. Hill, Ashley J. Kennedy, Kristen M. Roberts, Ken M. Riedl , Elizabeth M. Grainger, and Steven K. Clinton (2021). Considerations for Use of the Phenol-Explorer Database to Estimate Dietary (Poly)phenol Intake. Journal of the Academy of Nutrition and Dietetics, 121 (5).

Erica Kosmerl, Diana Rocha-Mendoza, Joana Ortega-Anaya, Rafael Jiménez-Flores, and Israel García-Cano (2021). Improving Human Health with Milk Fat Globule Membrane, Lactic Acid Bacteria, and Bifidobacteria. Microorganisms, 9 (2).

Joana Ortega-Anaya, Alice Marciniak, and Rafael Jiménez-Flores (2021). Milk fat globule membrane phospholipids modify adhesion of Lactobacillus to mucus-producing Caco-2/Goblet cells by altering the cell envelope. Food Research International, 146.

Israel García-Cano, Po-Wei Yeh, Diana Rocha-Mendoza, Rafael Jiménez-Flores (2021). Supercritical CO2 treatment reduces the antigenicity of buttermilk β-lactoglobulin and its inflammatory response in Caco-2 cells. JDS Communications, 2 (1).

Ni Shi, Xiaoxin Chen, and Tong Chen (2021). Anthocyanins in Colorectal Cancer Prevention Review. antioxidants, 10 (10).

Junnan Gu, Jennifer M. Thomas-Ahner, Kenneth M. Riedl, Michael T. Bailey, Yael Vodovotz, Steven J. Schwartz, Steven K. Clinton (2019). Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice. Molecular Nutrition and Food Research, 63 (8).

Jacob M Allen, Robert M Jaggers, Lindsey M Solden, Brett R Loman, Ronald H Davies, Amy R Mackos, Christopher A Ladaika, Brian M Berg, Maciej Chichlowski, and Michael T Bailey (2019). Dietary oligosaccharides attenuate stress-induced disruptions in immune reactivity and microbial B-vitamin metabolism. Frontiers in immunology, 10.

Austin Angelotti, Rachel M. Cole, Patrick M. Schnell, Susan K. Raatz, and Martha A. Belury (2019). Evaluation of a Rapid Assessment Questionnaire Using a Biomarker for Dietary Intake of n-3 Fatty Acids. Lipids, 54 (5).

J. Gu , J.M. Thomas-Ahner, K.M. Riedl, M.T. Bailey, Y. Vodovotz, S.J. Schwartz, and S.K. Clinton (2019). Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice. Molecular Nutrition & Food Research, 63 (8).

B. Abbaoui, C.R. Lucas , K.M. Riedl, S.K. Clinton, and A. Mortazavi (2018). Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention. Molecular Nutrition & Food Research, 62 (18).

Cichon MJ, Moran NE, Riedl KM, Schwartz SJ, Clinton SK (2017). Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using 13C-Labeling and QTOF-MS. Metabolites, 8 (1).

Cichon MJ, Riedl KM, Wan L, Thomas-Ahner JM, Francis DM, Clinton SK, Schwartz SJ. (2017). Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice. Molecular Nutrition & Food Research, 61 (12).

B.M. Cotten, S.A. Diamond, T. Banh , Y.H. Hsiao, R.M. Cole , J. Li , C.T. Simons, R.S. Bruno, M.A. Belury, and Y. Vodovotz (2017). Raspberry ketone fails to reduce adiposity beyond decreasing food intake in C57BL/6 mice fed a high-fat diet. Food & Function, 8 (4).

K.M. Roberts, E.M. Grainger, J.M. Thomas-Ahner, A. Hinton, J. Gu , K.M. Riedl, Y. Vodovotz , R. Abaza , S.J. Schwartz, and S.K. Clinton (2017). Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men. Molecular Nutrition & Food Research, 61 (3).

Besma Abbaoui, Kelly H. Telu, Christopher R. Lucas, Jennifer M. Thomas-Ahner , Steven J. Schwartz , Steven K. Clinton, Michael A. Freitas,  and Amir Mortazavi (2017). The impact of cruciferous vegetable isothiocyanates on histone acetylation and histone phosphorylation in bladder cancer. Journal of Proteomics, 156 (6).

Jinhui Li , Teryn N Sapper , Eunice Mah, Swetha Rudraiah, Kevin E Schill, Chureeporn Chitchumroonchokchai, Meredith V Moller, Joshua D McDonald, Philip R Rohrer, José E Manautou, and Richard S Bruno (2016). Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet. Molecular Nutrition & Food Research, 60 (4).

Jinyu Xu, Jeffrey D. Galley, Michael T. Bailey, Jennifer M. Thomas-Ahner, Steven K. Clinton, and Susan E. Olivo-Marston (2016). The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice. Scientific Reports, 6.
Rachel E. Kopec, Jonathan Schick, Kathleen L. Tober, Ken M. Riedl, David M. Francis, Gregory S. Young, Steven J. Schwartz, and Tatiana M. Oberyszyn (2015). Sex Differences in Skin Carotenoid Deposition and Acute UVB-Induced Skin Damage in SKH-1 Hairless Mice after Consumption of Tangerine Tomatoes. Molecular Nutrition & Food Research, 59 (12).

Thomas SE, Harrison EH. 2016. Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins. J Lipid Res. Epub ahead of print.

Smith JW, Ford NA, Thomas-Ahner JM, Moran NE, Bolton EC, Wallig MA, Clinton SK, Erdman JW. 2016. Mice lacking β-carotene-15,15’-dioxygenase (BCO1) exhibit reduced serum testosterone, prostatic androgen receptor signaling, & prostatic cellular proliferation. Am J Physiol Regul Integr Comp Physiol. Epub ahead of print.

Costabile BK, Kim YK, Iqbal J, Zuccaro MV, Wassef L, Narayanasamy S, Curley RW, Harrison EH, Hussain MM, Quadro L. 2016. β-Apo-10’-carotenoids modulate placental microsomal triglyceride transfer protein expression and function to optimize transport of intact β-carotene to the embryo. J Biol Chem. 291(35):18525–35.

Shi N, Riedl KM, Schwartz SJ, Zhang X, Clinton SK, Chen T. 2016. Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats. J Funct Foods, 27: 84–94.

Dela Seña C, Sun J, Narayanasamy S, Riedl KM, Yuan Y, Curley RW, Schwartz SJ, Harrison EH. 2016. Substrate specificity of purified recombinant chicken β-carotene 9’,10′-oxygenase (BCO2). J Biol Chem. 291(28), 14609–19.

Cardenas H, Arango D, Nicholas C, Duarte S, Nuovo GJ, He W, Voss OH, Gonzalez-Mejia ME, Guttridge DC, Grotewold E, Doseff AI. (2016). Dietary apigenin exerts immune-regulatory activity in vivo by reducing NF-κB Activity, halting leukocyte infiltration and restoring normal metabolic function. Int J Mol Sci, 17(3).

Li J, Sapper TN, Mah E, Rudraiah S, Schill KE, Chitchumroonchokchai C, Moller MV, McDonald JD, Rohrer PR, Manautou JE, Bruno RS. 2016. Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet. Mol Nutr Food Res. 60(4):858-70.

Xu J, Galley JD, Bailey MT, Thomas-Ahner JM, Clinton SK, Olivo-Marston SE. 2016. The impact of dietary energy intake early in life on the colonic microbiota of adult mice. Sci Rep. 6:19083.

Ke JY, Cole RM, Hamad EM, Hsiao YH, Cotten BM, Powell KA, Belury MA. 2016. Citrus Flavonoid, Naringenin, Increases Locomotor Activity and Reduces Diacylglycerol Accumulation in Skeletal Muscle of Obese Ovariectomized Mice. Mol Nutr Food Res. 60(2):313-24.

DiSilvestro RA, Thomas S, Harrison E, Epitropoulos A. 2015. A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people. Nutr J, 14, 104.

Gressel KL, Duncan FJ, Oberyszyn TM, La Perle KM, Everts HB. 2015. Endogenous retinoic acid required to maintain the epidermis following ultraviolet light exposure in SKH-1 hairless mice. Photochem Photobiol. 91(4), 901–908.

Roy S, Brasky TM, Belury MA, Krishnan S, Cole RM, Marian C, Yee LD, Llanos AA, Freudenheim JL, Shields PG. 2015. Associations of erythrocyte ω-3 fatty acids with biomarkers of ω-3 fatty acids and inflammation in breast tissue. Int J Cancer. 137(12), 2934–46.

Chatthongpisut R, Schwartz SJ, Yongsawatdigul J. 2015. Antioxidant activities and antiproliferative activity of Thai purple rice cooked by various methods on human colon cancer cells. Food Chem. 188: 99-105.

Arango D, Diosa-Toro M, Rojas-Hernandez LS, Cooperstone JL, Schwartz SJ, Mo X, Jiang J, Schmittgen TD, Doseff AI. 2015. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Mol Nutr Food Res. 59(4):763-72.

Wang C, Jiang H, Yuen JJ, Lee S, Narayanasamy S, Curley RW, Harrison EH, Blaner WS. 2015. Actions of β-apo-carotenoids in differentiating cells: Differential effects in P19 cells and 3T3-L1 adipocytes.. Arch Biochem Biophys. 572:2-10.

Raghuvanshi S, Reed V, Blaner W, Harrison E. 2015. Cellular localization of β-carotene 15,15′ oxygenase-1 (BCO1) and β-carotene 9′,10′ oxygenase-2 (BCO2) in rat liver and intestine. Arch Biochem Biophys. 572:19-27

Ke J, Kliewer KL, Hamad EM, Cole RM, Powell KA, Andridge RR, Straka SR, Yee LD, Belury MA. 2015. The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in mice. Nutr Metab. 13;12:1.

Shen Q, Riedl KM, Cole RM, Lehman C, Xu L, Alder H, Belury MA, Schwartz SJ, Ziouzenkova O. 2015. Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation. J Agric Food Chem. 76(8):650-8.

Chung M-Y, Mah E, Masterjohn C, Noh SK, Park HJ, Clark RM, Park Y-K, Lee J-Y, Bruno RS. 2015. Green tea lowers hepatic COX-2 and prostaglandin E2 in rats with dietary fat-induced nonalcoholic steatohepatitis. J Med Food. 18(6):648-55.

Shi N, Clinton S, Liu Z, Wang Y, Riedl K, Schwartz S, Zhang X, Pan Z, Chen T. 2015. Strawberry phytochemicals inhibit azoxymethane/dextran sodium sulfate-induced colorectal carcinogenesis in Crj: CD-1 mice. Nutrients. 7(3):1696–1715.

Gutierrez-Orozco F, Thomas-Ahner JM, Galley JD, Bailey MT, Clinton SK, Lesinski GB, Failla ML. 2015. Intestinal microbial dysbiosis and colonic epithelial cell hyperproliferation by dietary α-mangostin is independent of mouse strain. Nutrients. 7(2):764–84.

Warner BM, Casto BC, Knobloch TJ, Accurso BT, Weghorst CM. 2014. Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 118(6):674–83.

Wan L, Tan H-L, Thomas-Ahner JM, Pearl DK, Erdman JW, Moran NE, Clinton SK. 2014. Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Cancer Prev Res. 7(12):1228–39.

Sun J, Narayanasamy S, Curley RW, Harrison EH. 2014. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 289(48):33118–24.

Lee S-A, Jiang H, Trent CM, Yuen JJ, Narayanasamy S, Curley RW, Harrison EH, Goldberg IJ, Maurer MS, Blaner WS. 2014. Cardiac dysfunction in β-carotene-15,15’-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism. Am J Physiol Hear. Circ Physiol. 307(11):H1675–84.

Bricker GV, Riedl KM, Ralston RA, Tober KL, Oberyszyn TM, Schwartz SJ. 2014. Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane. Mol Nutr Food Res. 58(10):1991-2000.

Joehlin-Price AS, Elkins CT, Stephens JA, Cohn DE, Knobloch TJ, Weghorst CM, Suarez AA. 2014. Comprehensive evaluation of caspase-14 in vulvar neoplasia: An opportunity for treatment with black raspberry extract. Gynecol Oncol. 135(3):503–9.

Liu AG, Juvik JA, Jeffery EH, Berman-Booty LD, Clinton SK, Erdman JW. 2014. Enhancement of broccoli indole glucosinolates by methyl jasmonate treatment and effects on prostate carcinogenesis. J Med Food. 17(11):1177-82.

Kamonpatana K, Failla ML, Kumar PS, Giusti MM. 2014. Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa. J Agric Food Chem. 62(29):6903-10.

Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB. 2014. Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother. 63(9):889-900.

Failla ML, Chitchumronchokchai C, Ferruzzi MG, Goltz SR, Campbell WW. 2014. Unsaturated fatty acids promote bioaccessibility and basolateral secretion of carotenoids and α-tocopherol by Caco-2 cells. Food Funct. 5:1101–12.

Lakshmanan A, Doseff AI, Ringel MD, Saji M, Rousset B, Zhang X, Jhiang SM. 2014. Apigenin in combination with AKT inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. Thyroid. 24:878–87.

Dela Seña C, Riedl KM, Narayanasamy S, Curley RW, Schwartz SJ, Harrison EH. 2014. The human enzyme that converts dietary provitamin a carotenoids to vitamin A is a dioxygenase. J Biol Chem. 289:13661–6.

Gutierrez-Orozco F, Thomas-Ahner JM, Berman-Booty LD, Galley JD, Chitchumroonchokchai C, Mace T, Suksamrarn S, Bailey MT, Clinton SK, Lesinski GB, Failla ML. 2014. Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice. Mol Nutr Food Res. 58(6):1226-38.

Tran TH, Guo Y, Song D, Bruno RS, Lu X. 2014. Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability. J Pharm Sci;103:840–52.

Tan HL, Moran NE, Cichon MJ, Riedl KM, Schwartz SJ, Erdman JW Jr, Pearl DK, Thomas-Ahner JM, Clinton SK. 2014. β-carotene-9′,10′-oxygenase status modulates the impact of dietary tomato and lycopene on hepatic nuclear receptor-, stress-, and metabolism-related gene expression in mice. J Nutr. 144(4):431-9.

Shen Q, Chitchumroonchokchai C, Thomas JL, Gushchina L V, Disilvestro D, Failla ML, Ziouzenkova O. 2013. Adipocyte reporter assays: Application for identification of anti-inflammatory and antioxidant properties of mangosteen xanthones. Mol Nutr Food Res. 58(2):239-47.

Dela Sena C, Narayanasamy S, Riedl KM, Curley RW, Schwartz SJ, Harrison EH. 2013. Substrate specificity of purified recombinant human β-carotene 15,15’-oxygenase (BCO1). J Biol Chem. 288(52):37094-103.

Moran NE, Clinton SK, Erdman JW. 2013. Differential bioavailability, clearance, and tissue distribution of the acyclic tomato carotenoids, lycopene and phytoene, in Mongolian gerbils. J Nutr. 143(12):1920-6.

Duarte S, Arango D, Parihar A, Hamel P, Yasmeen R, Doseff AI. 2013. Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. Int J Mol Sci. 14(9):17664-79.

Arango D, Morohashi K, Yilmaz A, Kuramochi K, Parihar A, Brahimaj B, Grotewold E, Doseff AI. 2013. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. PNAS;110(24):E2153-62.

Li Y, Zhang T, Li X, Zou P, Schwartz SJ, Sun D. 2013. Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation. Mol Nutr Food Res. 57(12):2128-36.

Gushchina L V, Yasmeen R, Ziouzenkova O. 2013. Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner. Arch Biochem Biophys. 539(2):239–47.

Liu M-J, Bao S, Bolin ER, Burris DL, Xu X, Sun Q, Killilea DW, Shen Q, Ziouzenkova O, Belury MA, Failla ML, Knoell DL. 2013. Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet. J Nutr. 143(7):1036–45.

Victoria-Campos CI, Ornelas-Paz J de J, Yahia EM, Failla ML. 2013. Effect of the interaction of heat-processing style and fat type on the micellarization of lipid-soluble pigments from green and red pungent peppers (Capsicum annuum). J Agric Food Chem. 61(15):3642–53.

Zuniga K, Clinton SK, Erdman JW. 2013. The interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model. Cancer Prev Res. 6(6):548-557.

Berman-Booty LD, Chu P-C, Thomas-Ahner JM, Bolon B, Wang D, Yang T, Clinton SK, Kulp SK, Chen C. 2013. Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent. Cancer Prevention Research. 6(3):232–41.

Gutierrez-Orozco F, Chitchumroonchokchai C, Lesinski GB, Suksamrarn S, Failla ML. 2013. α-Mangostin: Anti-inflammatory activity and metabolism by human cells. J Agric Food Chem. 61(16):3891-3900.

Moran NE, Rogers RB, Lu C, Conlon LE, Lila MA, Clinton SK, Erdman JW Jr. 2013. Biosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with 13C-glucose. Food Chem. 139(1-4):631-9.

Arango D, Parihar A, Villamena FA, Wang LW, Freitas MA, Grotewold E, Doseff AI. 2012. Apigenin induces DNA damage through the PKC delta-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochemical Pharmacology. 84(12):1571-1580.

Chitchumroonchokchai C, Thomas-Ahner JM, Li J, Riedl KM, Nontakham J, Suksumrarn S, Clinton SK, Kinghorn AD, Failla ML. 2013. Anti-tumorigenicity of dietary alpha-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol Nutr Food Res. 57(2):203-211.

Yee LD, Agarwal D, Rosol TJ, Lehman A, Tian M, Hatton J, Heestand J, Belury MA, Clinton SK. 2013. The inhibition of early stages of HER-2/neu-mediated mammary carcinogenesis by dietary n-3 PUFAs. Mol Nutr Food Res. 57(2):320-327.

Harrison EH, dela Sena C, Eroglu A, Fleshman MK. 2012. The formation, occurrence, and function of beta-apocarotenoids: beta-carotene metabolites that may modulate nuclear receptor signaling. Amer J Clin Nutr. 96(5):1189s-1192s.

Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A. 2012. Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: Characterization, metabolism, and interconversion. Mol Nutr Food Res. 56:1-13.

Kamonpatana K, Giusti MM, Chitchumroonchokchai C, Moreno Cruz M, Riedl KM, Kumar P, Failla ML. 2012. Susceptibility of anthocyanins to ex vivo degradation in human saliva. Food Chem. 135(2):738-747.

Ford NA, Moran NE, Smith JW, Clinton SK, Erdman JW. 2012. An interaction between carotene-15,15′-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone. International Journal of Cancer. 131(2):E143-E148.

Harrison EH. 2012. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochim Biophys Acta. 1821(1):70-77.

Li Y, Karagoz GE, Seo YH, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rudiger SG, Sun D. 2012. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90. J Nutr Biochem. 23(12):1617-26.

Hostetler G, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI. 2012. Flavone deglycosylation increases their anti-inflammatory activity and absorption. Mol Nutr Food Res. 56(4):558-569.

Eroglu A, Hruszkewycz DP, Dela Sena C, Narayanasamy S, Riedl KM, Kopec RE, Schwartz SJ, Curley RW, Jr., Harrison EH. 2012. Naturally-occurring eccentric cleavage products of provitamin a beta-carotene function as antagonists of retinoic acid receptors. J Biol Chem. 287(19):15886-15895.

Zhang ZX, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CM. 2011. A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecologic Oncology. 123(2):401-406.

Li Y, Zhang T, Schwartz SJ, Sun D. 2011. Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr Cancer. 63(7):1151-1159.

Tian M, Kliewer KL, Asp ML, Stout MB, Belury MA. 2011. C9t11-conjugated linoleic acid-rich oil fails to attenuate wasting in colon-26 tumor-induced late-stage cancer cachexia in male CD2F1 mice. Mol Nutr Food Res. 55(2):268-277.

Stout MB, Liu LF, Belury MA. 2011. Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C epsilon in mice. Mol Nutr Food Res. 55(7):1010-1017.

Li Y, Wicha MS, Schwartz SJ, Sun D. 2011. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem. 22(9): 799-806.

Johnson JL, Bomser JA, Scheerens JC, Giusti MM. 2011. Effect of black raspberry (Rubus occidentalis l.) extract variation conditioned by cultivar, production site, and fruit maturity stage on colon cancer cell proliferation. J Agric Food Chem. 59(5):1638-1645.

Shmarakov I, Fleshman MK, D’Ambrosio DN, Piantedosi R, Riedl KM, Schwartz SJ, Curley RW, Jr., von Lintig J, Rubin LP, Harrison EH, Blaner WS. 2010. Hepatic stellate cells are an important cellular site for beta-carotene conversion to retinoid. Arch Biochem Biophys. 504(1):3-10.

Marsh RS, Yan Y, Reed VM, Hruszkewycz D, Curley RW, Harrison EH. 2010. {beta}-apocarotenoids do not significantly activate retinoic acid receptors {alpha} or {beta}. Exp Biol Med (Maywood). 235(3):342-348.

Li YY, Zhang T, Korkaya H, Liu SL, Lee HF, Newman B, Yu YK, Clouthier SG, Schwartz SJ, Wicha MS, Sun DX. 2010. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 16(9):2580-2590.

Ford NA, Clinton SK, von Lintig J, Wyss A, Erdman JW, Jr. 2010. Loss of carotene-9′,10′-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr. 140(12):2134-2138.

Lechner JF, Wang L-S, Rocha CM, Larue B, Henry C, McIntyre CM, Riedl KM, Schwartz SJ, Stoner GD. 2010. Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. J Medicinal Food. 13(3):733-739.

Tuntipopipat S, Muangnoi C, Failla ML. 2009. Anti-inflammatory activities of extracts of Thai spices and herbs with lipopolysaccharide-activated RAW 264.7 murine macrophages. J Medicinal Food. 12(6):1213-1220.

Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD. 2009. Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. Nutr Cancer. 61(6):816-826.

Lechner JF, Reen RK, Dombkowski AA, Cukovic D, Salagrama S, Wang LS, Stoner GD. 2008. Effects of a black raspberry diet on gene expression in the rat esophagus. Nutr Cancer. 60 Suppl 1:61-69.

Grainger EM, Canene-Adams K, Erdman JW, Jr., Clinton SK. 2008. Tomatoes and components as modulators of experimental prostate carcinogenesis. In: Tomatoes and tomato products: Nutritional, medicinal, and therapeutic properties. Eds. Preedy VR, Watson RR. Science Publishers, Inc, Enfield.

Duncan FJ, Martin JR, Wulff BC, Stoner GD, Tober KL, Oberyszyn TM, Kusewitt DF, Van Buskirk AM. 2009. Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation. Cancer Prev Res. 2(7):665-672.

Purushotham A, Tian M, Belury MA. 2009. The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells. Molecular Nutrition & Food Research. 53(2):300-307.

Raghavamenon A, Garelnabi M, Babu S, Aldrich A, Litvinov D, Parthasarathy S. 2009. alpha-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis. Antioxidants & Redox Signaling. 11(6):1237-1248.

Li YY, Zhang T, Schwartz SJ, Sun DX. 2009. New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential. Drug Resist. Update. 12(1-2):17-27.

Dworkin AM, Tober KL, Duncan FJ, Yu LB, VanBuskirk AM, Oberyszyn TM, Tolland AE. 2009. Chromosomal Aberrations in UVB-Induced Tumors of Immunosuppressed Mice. Genes Chromosomes & Cancer. 48(6):490-501.

Martin J, Duncan FJ, Keiser T, Shin S, Kusewitt DF, Oberyszyn T, Satoskar AR, VanBuskirk AM. 2009. Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet-B (UVB) -induced nonmelanoma skin cancer (NMSC). Faseb J. 23(3):720-730.

Benavides F, Oberyszyn TM, VanBuskirk AM, Reeve VE, Kusewitt DF. The hairless mouse in skin research. J Dermatol Sci. Jan 2009;53(1):10-18.

Gonzalez-Mejia ME, Doseff AI. Regulation of monocytes and macrophages cell fate. Frontiers in Bioscience. Jan 2009;14:2413-2431.

Wang XY, Colby JKL, Rengel RC, Fischer SM, Clinton SK, Klein RD. Overexpression of Cyclooxygenase-2 (COX-2) in the Mouse Urinary Bladder Induces the Expression of Immune- and Cell Proliferation-Related Genes. Molecular Carcinogenesis. Jan 2009;48(1):1-13.

Jing P, Bomser JA, Schwartz SJ, He J, Magnuson BA, Giusti MM. Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. J Agric Food Chem. 2008 Oct; 56(20):9391-98.

Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF. Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res. 2008 Aug;68(15):6460-6467.

During A, Doraiswamy S, Harrison EH. Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. J Lipid Res 2008 Aug;49(8):1715-24.

Steinhour E, Sherwani SI, Mazerik JN, Ciapala V, O’Connor Butler E, Cruff JP, Magalang U, Parthasarathy S, Sen CK, Marsh CB, Kuppusamy P, Parinandi NL. Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A(2), lipoxygenase, and cyclooxygenase. Mol Cell Biochem 2008 Aug;315(1-2):97-112.

Mallery SR, Zwick JC, Pei P, Tong M, Larsen PE, Shumway BS, Lu B, Fields HW, Mumper RJ, Stoner GD. Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res. 2008 Jun;68(12):4945-4957.

Powolny AA, Wang SH, Carlton PS, Hoot DR, Clinton SK. Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats. Mol Carcinog 2008 Jun;47(6):458-65.

Shumway BS, Kresty LA, Larsen PE, Zwick JC, Lu B, Fields HW, Mumper RJ, Stoner GD, Mallery SR. Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin.Cancer Res. Apr 15 2008;14(8):2421-2430.

Brophy LT, Litvinov D, Parthasarathy S. Potential modulation of cholesterol homeostasis by sesamol [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E127.

Brophy LT, Selvarajan K, Jaichander P, Parthasarathy S. Atheroprotective role of sesamol: Modulation of the lipid profile [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E59.

Litvinov D, Garelnabi MO, Parthasarathy S. Lipid peroxide decomposition product azelaic acid may promote calcification in atherosclerosis [Abstract]. In: Arteriosclerosis Thromb Vasc Bio; Jun; Atlanta, GA. Philadelphia, PA: Lippincott Williams and Wilkins; 2008. p. E84.

Tulio AZ, Reese RN, Wyzgoski FJ, Rinaldi PL, Fu R, Scheerens JC, Miller AR. Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. J Agric Food Chem 2008 Mar;56(6):1880-8.

Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. Jan 2008;49(1):98-106.

Albrecht DS, Clubbs EA, Ferruzzi M, Bomser JA. Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation. Chem Biol Interact 2008 Jan;171(1):89-95.

Li J, Zhang D, Stoner GD, Huang C. Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog 2008 Apr;47(4):286-94.

Purushotham A, Shrode GE, Wendel AA, Liu LF, Belury MA. 2007. Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult wistar rats. J Nutr Biochem. 18(10):676.

Oonsivilai R, Cheng C, Bomser J, Ferruzzi MG, Ningsanond S. Phytochemical profiling and phase II enzyme-inducing properties of Thunbergia laurifolia Lindl. (RC) extracts. J Ethnopharmacol 2007 Dec;114(3):300-6.

Parthasarathy S, Babu S. Alpha-keto acids prevent the breakdown of lipid peroxides: Potential therapeutic value in diabetes [Abstract]. In: Free Rad Biol Med; Nov; New York, NY: Elsevier Science Inc.; 2007. p. S105.

Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E, Doseff AI. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol 2007 Nov;179(10):7121-7.

Clubbs EA, Bomser JA. Glycitein activates extracellular signal-regulated kinase via vascular endothelial growth factor receptor signaling in nontumorigenic (RWPE-1) prostate epithelial cells. J Nutr Biochem 2007 Aug;18(8):525-32.

Voss OH, Batra S, Kolattukudy SJ, Gonzalez-Mejia ME, Smith JB, Doseff AI. Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J Biol Chem 2007 Aug;282(34):25088-99.

Trasino SE, Harrison EH, Wang TT. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood) 2007 Jun;232(6):762-71.

Huang C, Zhang D, Li J, Tong Q, Stoner GD. Differential inhibition of UV-induced activation of NF kappa B and AP-1 by extracts from black raspberries, strawberries, and blueberries. Nutr Cancer 2007 Jul;58(2):205-12.

Reen RK, Dombkowski AA, Kresty LA, Cukovic D, Mele JM, Salagrama S, Nines R, Stoner GD. Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 2007 Jul;67(13):6484-92.

Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X, Chen CS. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicol Pathol 2007;35(4):549-61.

Linke T, Doraiswamy S, Harrison EH. Rat plasma proteomics: effects of abundant protein depletion on proteomic analysis. J Chromatogr B Analyt Technol Biomed Life Sci 2007 Apr;849(1-2):273-81.

Mallery SR, Stoner GD, Larsen PE, Fields HW, Rodrigo KA, Schwartz SJ, Tian Q, Dai J, Mumper RJ. Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention. Pharm Res 2007 Apr;24(4):728-37.

Zhou XD, Smith AM, Failla ML. Estrogen status alters tissue distribution of oral dose of Se-75-selenite and liver mRNA levels of SelP and GPx [Abstract]. In: FASEB J; Apr; Bethesda, MD: Federation Amer Soc Exp Biol; 2007. p. A717.

Long AC, Colitz CMH, Bomser JA. Regulation of gap junction intercellular communication in primary canine lens epithelial cells: Role of protein kinase C. Current Eye Res 2007 Mar;32(3):223-31.

Belury MA, Kavanaugh CJ, Liu KL. Conjugated linoleic acid modulates phorbol ester-induced PPARdelta and K-FABP mRNA expression in mouse skin. Nutr Res 2007;27(1):48-55.

Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW,Jr. Combinations of tomato and broccoli enhance antitumor activity in Dunning R3327-H prostate adenocarcinomas. Cancer Res 2007 Jan;67(2):836-43.

Higashi Y, Sukhanov S, Parthasarathy S, Delafontaine P. Oxidized low-density lipoprotein down-regulates insulin-like growth factor 1 receptor via enhanced generation of nitric oxide and reactive oxygen species in human aortic smooth muscle cells [Abstract]. In: J Investigative Med; Jan; Hamilton, Ontario: BC Deckter Inc; 2007. p. S247.

Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury MA, Adams LS, Williams D. Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 2006 Dec;66(24):12026-34.

Guo Y, Wang S, Hoot DR, Clinton SK. Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biochem 2006 Dec;18(6):408-17.

Hwang H, Chen T, Nines RG, Shin HC, Stoner GD. Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols. Int J Cancer 2006 Dec;119(12):2742-9.

Chen T, Rose ME, Hwang H, Nines RG, Stoner GD. Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. Carcinogenesis 2006 Nov;27(11):2301-7.

Vargo MA, Voss OH, Poustka F, Cardounel AJ, Grotewold E, Doseff AI. Apigenin-induced apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 2006 Sep;72(6):681-92.

Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG. Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis 2006 Aug;27(8):1617-26.

Rodrigo KA, Rawal Y, Renner RJ, Schwartz SJ, Tian Q, Larsen PE, Mallery SR. Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 2006 Apr;54(1):58-68.

Chen T, Hwang H, Rose ME, Nines RG, Stoner GD. Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res 2006 Mar;66(5):2853-9.

Chitchumroonchokchai C, Failla ML. Inhibition of lipid peroxidation and stress signaling by synergistic antioxidant nutrients in human lens epithelial cells [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A1015.

Clubbs EA, Bomser JA. Isoflavone-induced activation of extracellular signal-regulated kinase (ERK 1/2) in non-tumorigenic prostate epithelial cells [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A1014.

Oonsivilai R, Cheng C, Ningsanond S, Bomser JA, Ferruzzi MG. Induction of quinone reductase activity in marine hepatoma cells by extracts of Thunbergia laurifolia Lindl [Abstract]. In: FASEB J; Mar; Bethesda, MD: Federation Amer Soc Exp Biol; 2006. p. A154.

Wang X, Clubbs EA, Bomser JA. Genistein modulates prostate epithelial cell proliferation via estrogen- and extracellular signal-regulated kinase-dependent pathways. J Nutr Biochem 2006 Mar;17(3):204-10.

Bhaskaran S, Santanam N, Penumetcha M, Parthasarathy S. Inhibition of atherosclerosis in low-density lipoprotein receptor-negative mice by sesame oil. J Med Food 2006 Jan;9(4):487-90.

Huang C, Li J, Song L, Zhang D, Tong Q, Ding M, Bowman L, Aziz R, Stoner GD. Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res 2006 Jan;66(1):581-7.

Lu H, Li J, Zhang D, Stoner GD, Huang C. Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes. Nutr Cancer 2006 Jan;54(1):69-78.

Reen RK, Nines R, Stoner GD. Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats. Nutr Cancer 2006 Jan;54(1):47-57.

Stoner GD, Chen T, Kresty LA, Aziz R, Reinemann T, Nines R. Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer 2006 Jan;54(1):33-46.

Zikri NN, Hecht SS, Carmella SG, Auer H, Chen T, Stoner GD. Effects of black raspberry components on growth and gene expression in rat esophageal epithelial cells [Abstract]. In: Cancer Epidemiol;Biomarkers Prev; Nov; Philadelphia, PA: Amer Assoc Cancer Research; 2005. p. 2751S.

Yee LD, Young DC, Rosol TJ, Vanbuskirk AM, Clinton SK. Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPAR gamma ligand rosiglitazone. J Nutr 2005 Jan;135(5):983-8.

Gu YH, Belury MA. Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes. Cancer Lett 2005 Mar;220(1):21-8.

Mertens-Talcott SU, Bomser JA, Romero C, Talcott ST, Percival SS. Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. J Nutr 2005 Mar;135(3):609-14.

Han C, Ding H, Casto B, Stoner GD, D’Ambrosio SM. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 2005 Mar;51(2):207-17.

Hudson TS, Stoner GD, Morse MA, Young H, Mallery SR. Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. Toxicol Lett 2005 Mar;155(3):427-36.

King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 2005 Jan;151(2):143-9.