Thomas Mace, Ph.D.

Assistant Professor
Comprehensive Cancer Center
Office of Health Sciences

420 W 12th Ave,
Columbus, OH 43210

(614) 366-3247

As a member of the Translational Therapeutics Program at the OSUCCC – James, my research is focused on translational tumor immunology, namely discovering new targets and pathways in the tumor microenvironment that can lead to improvements in patient responses to immune-based therapeutics. In particular, my laboratory seeks to better understand the pancreatic tumor microenvironment and determine the mechanisms of resistance to immune-based therapeutics.

I am investigating how cell surface proteins (e.g., CD200) expressed by the tumor and stromal cells promote the expansion and function of immunosuppressive cell types like myeloid-derived suppressor cells (MDSC), as well as how these immunosuppressive immune populations affect cancer-induced cachexia, a debilitating syndrome in patients with pancreatic cancer. My laboratory is also investigating dietary nutritional intervention to modulate inflammation in chronic diseases and cancer.

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