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PUBLISHED ARTICLES
Han CJ, Ning X, Burd CE, Spakowicz DJ, Tounkara F, Kalady MF, Noonan AM, McCabe S, Von Ah D. Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis. Cancers (Basel). 2024 Jul 20;16(14):2597. doi: 10.3390/cancers16142597. PMID: 39061235.
Grogan M, Hoyd R, Benedict J, Janse S, Williams N, Naughton M, Burd CE, Paskett ED, Rosko A, Spakowicz DJ, Presley CJ. The FITNESS study: longitudinal geriatric assessment, treatment toxicity, and biospecimen collection to assess functional disability among older adults with lung cancer. Front Aging. 2024 Jun 7;5:1268232. doi: 10.3389/fragi.2024.1268232. PMID: 38911592; PMCID: PMC11190321.
Rosko AE, Elsaid MI, Woyach J, Islam N, Lepola N, Urrutia J, Christian LM, Presley C, Mims A, Burd CE. Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy. J Cancer Surviv. 2024 Aug;18(4):1168-1178. doi: 10.1007/s11764-024-01591-6. Epub 2024 Apr 28. PMID: 38678524; PMCID: PMC11324703.
Madison AA, Burd CE, Andridge R, Wilson SJ, Bailey MT, Belury M, Spakowicz DJ, Malarkey W, Kiecolt-Glaser JK. Gut Microbiota Richness and Diversity Track with T Cell Aging in Healthy Adults. J Gerontol A Biol Sci Med Sci. 2023 Dec 20:glad276. doi: 10.1093/gerona/glad276. Epub ahead of print. PMID: 38123141.
Murphy BM*, Jensen DM*, Arnold TE, Aguilar-Valenzuela R, Hughes J, Posada V, Nguyen KT, Chu VT, Tsai KY, Burd CJ and Burd CE. The OSUMMER lines: A series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6. Pigment Cell Melanoma Res. 2023 Sep;36(5):365-377. doi: 10.1111/pcmr.13107. Epub 2023 Jun 21. PMID: 37341054 *authors contributed equally
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H and Lyden D. Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023 Jun;618(7964):374-382. doi: 10.1038/s41586-023-06114-4. Epub 2023 May 24. PMID: 37225988
Weiss TJ, Crawford ER, Rahman H, Liu T, Murphy BM, Posada V, Arnold TE, Gray S, Hennessey RC, Yu L, Zippin JH, D’Orazio JA, Burd CJ, Grossman D and Burd CE. Cell-intrinsic melanin fails to protect melanocytes from ultraviolet-mutagenesis. Pigment Cell Melanoma Res. 2023 Jan;36(1):6-18. doi: 10.1111/pcmr.13070. Epub 2022 Oct 9. PMID: 36148789.
Fell G, Rosko AE, Abel GA, Dumontier C, Higby KJ, Murillo A, Neuberg DS, Burd CE, Lane AA. Peripheral blood CD3+ T-cell gene expression biomarkers correlate with clinical frailty in patients with haematological malignancies. Br J Haematol. 2022 Jun 29. Epub ahead of print. PMID: 35766906.
Murphy BM, Terrell EM, Chirasani VR, Weiss TJ, Lew RE, Holderbaum AM, Dhakal A, Posada V, Fort M, Bodnar MS, Carey LM, Chen M, Burd CJ, Coppola V, Morrison DK, Campbell SL, Burd CE. Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. Nat Commun. 2022 Jun 7;13(1):3153. doi: 10.1038/s41467-022-30881-9. PMID: 35672316; PMCID: PMC9174180.
Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG Jr, Bojovic B, Cetrulo CL Jr, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE. Topical therapy for regression and melanoma prevention of congenital giant nevi. Cell. 2022 May 9:S0092-8674(22)00472-X. doi: 10.1016/j.cell.2022.04.025. Epub ahead of print. PMID: 35561684.
Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, LaPerle KMD, Burd CJ, Levine RS, Hunter AS and Burd CE. UVB mutagenesis differs in NRAS- and BRAF-mutant mouse models of melanoma. Life Sci Alliance. 2021 Jul 1;4(9): PMID: 26940869 *2021 LSI Highlighted Article (1 of 10 in Cancer Biology section)
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O’Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. An aged immune system drives senescence and ageing of solid organs. 2021 Jun;594(7861):100-105. PMID: 33981041.
Rosko AE, Wall S, Baiocchi R, Benson DM, Brammer JE, Byrd JC, Efebera YA, Maddocks K, Rogers KA, Jones D, Sucheston-Campbell L, Tang H, Ozer HG, Huang Y, Burd CE, Naughton MJ. Aging Phenotypes and Restoring Functional Deficits in Older Adults With Hematologic Malignancy. J Natl Compr Canc Netw. 2021 Mar 26:1-10. PMID: 33770752.
Phadke MS, Chen Z, Li J, Mohamed E, Davies MA, Smalley I, Duckett DR, Palve V, Czerniecki BJ, Forsyth PA, Noyes D, Adeegbe DO, Eroglu Z, Nguyen KT, Tsai KY, Rix U, Burd CE, Chen YA, Rodriguez PC, Smalley KSM. Targeted Therapy Given after Anti-PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity. Cancer Immunol Res. 2021 May;9(5):554-567. PMID: 33653716; PMCID: PMC8102376.
Rahman H, Kumar D, Liu T, Okwundu N, Lum D, Florell SR, Burd CE, VanBrocklin MW and Grossman D. Aspirin protects melanocytes and keratinocytes against UVB-induced DNA damage in vivo. J Invest Dermatol. 2021 Jan;141(1):132-141.e3. PMID: 32569596
Galloway JE, Holderbaum AM, Zhang S, Arya N, Norman R, Kiecolt-Glaser J, Carson WE, Yu L, Kendra KL and Burd CE. Markers of T cell biologic age predict immunotherapeutic discontinuation in a prospective clinical cohort study. Aging and Cancer. 2020; 1:58-70. PMID: 34337428
Pathak S, Stewart WCL, Burd CE, Hester ME, Greenberg DA. Brd2 haploinsufficiency delays aging and increases healthspan in C57B6/J mice. PLoS One. 2020 Jun 19;15(6):e0234910. PMID: 32559200
Burd CE*, Peng J, Laskowski BF, Hollyfield JL, Zhang S, Fadda P, Yu L, Andridge RR, and Kiecolt-Glaser J. Association of epigenetic age and p16INK4a with markers of T cell composition in a healthy cohort. J Gerontol A Biol Sci Med Sci. 2020 Gerontology. Nov 13;75(12):2299-2303 PMID: 32361724 *Corresponding author
Yousefzadeh MJ, Zhao J, Gurkar AU, McGowan SJ, Bukata C, Angelini L, Wade EA, Burd CE, Robbins PD and Niedernhofer L. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell. 2020 Mar;19(3):e13094. PMID: 31981461.
Lucas F, Pennell M, Huang Y, Benson DM, Efebera YA, Chaudhry M, Hughes T, Woyach JA, Byrd JC, Zhang S, Jones D, Guan X, Burd CE and Rosko AE. T-cell transcriptional profiling and immunophenotyping uncover LAG3 as a potential clinically significant target of immune modulation in multiple myeloma. Blood Marrow Transplant. 2020 Jan;26(1):7-15. PMID: 31445183
Murphy BM, Weiss TJ and Burd CE. Rapid Generation of Primary Murine Melanocyte and Fibroblast Culture. J Vis Exp. 2019 Jun 26;(148). PMID: 31305511
Yousefzadeh MJ, Melos K, Angelini L, Burd CE, Robbins PD, and Niedernhofer LJ. Mouse models of accelerated cellular senescence. Methods Mol. Biol. 2019 1896:203-230. PMID: 30474850
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos K, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, and Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan of aged mice. EBioMedicine, 2018 Oct;36:18-28. PMID: 30279143
Rosko AE, Benson DM, Efebera YA, Hofmeister C, Jaglowski S, Devine S, Bhatt G, Wildes TM, Huang Y, Dyko A, Jones D, Naughton MJ, Byrd JC and Burd CE. Use of a comprehensive frailty assessment to predict morbidity in patients with multiple myeloma undergoing transplant. J Geriatr Oncol., 2018 Jul 5. pii: S1879-4068(18)30157-7. PMID: 29983352
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz M-C, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RA, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti L, Opresko PL, Stolz DB, Watkins SC, Burd CE, St. Croix CM, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelly EE, and Niedernhofer L. Spontaneous DNA damage to the nuclear genome promotes senescence and aging. Redox Biology. 2018 Apr 13;17:259-273. PMID: 29747066
LaPak KM, Vroom DM, Garg AA, Guan X, Hays JL, Song JW and Burd CE. Melanoma-Associated Mutants within the Serine-Rich Domain of PAK5 Direct Kinase Activity to Mitogenic Pathways. Oncotarget. 2018 May 22;9(39):25386-25401. PMID:29875996
Echevarría-Vargas IM, Reyes-Uribe PI, Yin X, Krepler C, Kossenkov AV, Liu Q, Cheng C, Zhang G, Wei Z, Karakousis G, Xu W, Burd CE, Lu Y, Mills GB, Weeraratna A, Amaravadi R, Schuchter LM, Xu X, and Villanueva J. Co-targeting BET and MEJ as an effective salvage therapy for MAPK and checkpoint inhibitor resistant melanoma. EMBO Mol. Med. 2018 May;10(5) pii: e8446. PMID: 29650805
Hennessey RC, Holderbaum AM, Bonilla A, Delaney C, Gillahan JE, Tober KL, Oberyszyn TM, Zippin JH and Burd CE. Ultraviolet radiation accelerates NRAS-mutant melanomagenesis: a cooperative effect blocked by sunscreen. Pigment Cell Melanoma Res. 2017 Sep;30(5):477-487. PMID: 28544727
Guan X, LaPak KM, Hennessey RC, Yu CY, Shakya R, Zhang J,Burd CE. Stromal senescence by prolonged CDK4/6 inhibition potentiates tumor growth. Mol Cancer Res. 2017 Mar;15(3):237-249 PMID: 28039358 *AACR 2018 Highlighted article
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T,Burd CE, Lesinski GB. The exportin-1 inhibitor selinexor exerts superior anti-tumor activity when combined with T cell checkpoint inhibitors. Mol Cancer Ther. 2017 Mar;16(3):417-427. PMID:28148715
Souroullas GP, Jeck WR, Parker J, Liu J, Paulk J., Xiong J., Clark K., Fedoriw Y., Qi J., Burd C.E., Bradner JE, and Sharpless NE. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 methylation. Nat Med. 2016 Jun;22(6):632-40. PMCID: PMC4899144
Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J. The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent. 2016 Sep;30(9):1935-8. PMID: 27109513
Palmieri D, Scarpa M, Tessari A, Uka R, Amari F, Lee C, Richmond T, Sheetz T, Braddom A, Burd CE, Parvin J, Ludwig T, Croce C and Coppola V. Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells. 2016 Apr 5;7(14)18371-83. PMCID: 26943034
Kong G, Chang Y, Damnernsawad A, You X, Du J, Ranheim EA, Lee W, Ryu M, Zhou Y, Xing Y, Chang Q, Burd CE, and Zhang J. Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis. 2016 Jul;30(7):1542-51. PMID:27055865
Rosko A, Hofmeister C, Benson D, Efebera Y, Huang Y, Gillahan J, Byrd JC and Burd CE. Autologous hematopoietic stem cell transplant induces the molecular aging of T cells in multiple myeloma. Bone Marrow Transplantation. 2015 Oct;50(10):1379-81. PMCID: PMC4821192
Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL and Sharpless NE. Mutation-specific RAS oncogenicity explains N-RAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29. PMCID: PMC4258185
Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Hays DN and Sharpless NE. Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. Pigment Cell Melanoma Res. 2014 Jul;27(4):653-63. PMID:24628946
Sorrentino JA, Krishnamurthy J, Tilley S, Alb JG, Burd CE and Sharpless NE. p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. 2014 Jan 2;124(1):169-73. PMID:24334456
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Marzluff W Z, Liu J, Marzluff WF and Sharpless NE. Circular RNAs are abundant, conserved and associated with ALU repeats. 2013 Feb;19(2):141-57. PMID: 23249747
Burd CE, Sorrentino JA, Clark KS, Darr D, Krishnamurthy J, Deal A, Bardeesy N, Castrillo D, Beach DH, and Sharpless NE. Monitoring tumorigenesis and senescence in vivo with a p16INK4aluciferase model. 2013 Jan17;152(1-2):340-51. PMID: 23332765
Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, and Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 2010 Dec;6(12):e1001233. PMID: 21151960
Chen W, Hilton IB, Staudt MR, Burd CE, and Dittmer DP. Distinct p53, p53:LANA and LANA complexes in Kaposi sarcoma-associated herpesvirus (KSHV) lymphomas. J Virol. 2010 Apr; 84(8):3898-3908. PMID: 20130056
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim J, Thomas NE, and Sharpless NE. Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell. 2009 Aug; 8(4):439-48. PMID: 19485966
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim J, Thomas NE, and Sharpless NE. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS ONE. 2009 Apr; 4(4):e5027. PMID: 19343170
Petre CE, Sin S-H, and Dittmer DP. Functional p53 signaling in Kaposi’s sarcoma-associated herpesvirus lymphomas: implications for therapy. J Virol. 2007 Feb; 81(4):1912-22. PMID:17121789
Petre CE*, Burd CJ*, Morey LM, Wang, Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM, Li, J, Knudsen ES, Wong J, and Knudsen KE. The cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci. 2006 Feb; 103(7):2190-5. PMID:16461912 (*co-authorship)
Burd CJ, Petre CE, Moghadam H, Wilson EM, and Knudsen KE. Cyclin D1 binding to the androgen receptor NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR co-repression. Mol Endocrinol. 2005 Mar; 19(3): 607-20. PMID:15539430
Petre-Draviam CE, Burd CJ, Gladden A, Moghadam H, Diehl JA, and Knudsen KE. The central domain of cyclin D1 elicits nuclear receptor co-repressor activity. Oncogene. 2005 Jan; (24): 431-444. PMID:15558026
Petre-Draviam CE, Cook SL, Wetherill Y B, Marshall T, and Knudsen KE. Specificity of cyclin D1 for androgen receptor regulation. Cancer Research. 2003 Aug; 63(16): 4903-4913. PMID:12941814
Marshall TW, Link KA, Petre-Draviam CE, and Knudsen KE. Differential roles of the SWI/SNF complex on androgen responsive genes. J Biol Chem. 2003 Aug 15;278(33):30605-13. PMID:12775722
Wetherill YB, Petre CE, Monk KR, Puga A, and Knudsen KE. The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostate adenocarcinoma cells. Mol Cancer Ther. 2002 May; 1(7):515-24. PMID:12479269
Petre C E, Wetherill Y B, Danielson MD, and Knudsen KE. Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity. J Biol Chem. 2002 Jan 18; 277(3): 2207-15. PMID:11714699
Invited Book Chapters, Reviews and Commentaries
Christian LM, Kiecolt-Glaser JK, Cole SW, Burd CE, Madison AA, Wilson SJ, Rosko AE. Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers. Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Epub ahead of print. PMID: 38643954.
Christian LM, Wilson SJ, Madison AA, Prakash RS, Burd CE, Rosko AE, Kiecolt-Glaser JK. Understanding the health effects of caregiving stress: New directions in molecular aging. Ageing Res Rev. 2023 Oct 28;92:102096. doi: 10.1016/j.arr.2023.102096. Epub ahead of print. PMID: 37898293.
Murphy BM, Burd CE. The aging lung microenvironment awakens melanoma metastases. Cancer Cell. 2022 Aug 8;40(8):815-817. doi: 10.1016/j.ccell.2022.06.013. Epub 2022 Jul 21. PMID: 35868308.
Presley CJ, Gomes F, Burd CE, Kanesvaran R and Wong ML. Immunotherapy in Older Adults with Cancer. J Clin Oncol. Jul 1;39(19):2115-2127. PMID: 34043444.
Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021 May 10;39(5):610-631. PMID: 33545064.
Murphy BM and Burd CE. Can combination MEK and AKT inhibition help slay the giant congenital nevus? J Invest Dermatol. 2019 Sep;139(9):1857-1859. PMID: 31445573
Burd CE*, Gill MS*, Niedernhofer LJ, Robbins PD, Austad SN, Barzilai N and Kirkland JL. Barriers to the Pre-Clinical Development of Therapeutics that Target Aging Mechanisms. Gerontol A Biol Sci Med Sci. 2016 Aug 16 PMCID: PMC5055650
LaPak KM. and Burd CE. The Molecular Balancing Act of p16INK4a in Cancer and Aging. Mol Cancer Res. 2014;12:167-183. PMID:24136988
Burd CE and Sharpless NE. What’s so special about RB? Cancer Cell. 2010 Apr; 17(4):313-314. PMID:20385355
Petre CE and Dittmer DP. Liposomal daunorubicin as treatment for Kaposi’s Sarcoma. Int J Nanomedicine. 2007;2(3):277-88. PMID: 18019828
Knudsen, A.F. Fribourg, C. Petre, and Wetherill, Y. (2002) Androgen mediated regulation of the G-1S phase transition. Steroid hormones and Cell Cycle Regulation. Edited by K. Burnstein, Kluwer Academic Publishers, Norwell, Massachusetts, pp 91-111.