Dr. Chris Breuer, MD (Director of the Center for Regenerative Medicine, Division of Pediatric Surgery, OSU)

Dr. Gregory Behbehani, M.D., Ph.D. (Mass cytometry expert, OSU)

Mass cytometry, or CyTOF, is a powerful method that enables measurement of up to 50 parameters per single cell through the use of time-of-flight mass spectrometry and heavy-metal tagged antibodies. CyTOF immunophenotyping has been used to discover novel immune subsets and to identify cell signatures which differentiate patients with and without disease, stratify patients into groups corresponding with biologic markers of disease and severity of disease. The Division of Hematology’s new third-generation CyTOF mass cytometer (Helios) is housed in the Behbehani lab

Dr. Anjali Satoskar, M.D. (Renal and Transplant pathology expert, OSU)

Mouse kidney allografts from CCR5 KO recipients produce large quantities of alloantibody that lead to graft loss. Antibody-mediated rejection (AMR) in this mouse kidney transplant model reproduces the pathology of AMR in human kidney transplant recipients (microvascular inflammation/peritubular capillary margination, arteritis, and PTC C4d deposition).

Dr. Lang Li, Ph.D. (Bioinformatics expert, OSU)

Randy Brutkiewicz, Ph.D. (Innate immunologist, OSU)

The Brutkiewicz lab studies innate immunity with focus on natural killer T (NKT) cells. We have shown in our mouse models that type I NKT cells play a significant role in the generation of alloreactive responses following transplant (including humoral- and cellular-mediated rejection).

Mahmoud Abdel-Rasoul, M.S., M.P.H. (Statistical analysis, OSU)