Dr. Renee Bouley

Associate Professor of Biochemistry 

Department of Chemistry and Biochemistry

 

Contact Information: 

Email: Bouley.8@osu.edu

Office: Marion Science and Engineering (MSE) 110G

 

Full CV (updated July 2025)

 

Education and Training: 

2016–2019      Postdoctoral Research Fellow

University of Michigan, Life Sciences Institute and Department of Pharmacology

2016                Ph.D. Organic Chemistry

                        University of Notre Dame, Department of Chemistry and Biochemistry

Thesis Title: Development of New Antibacterial Agents for the Treatment of Methicillin-Resistant Staphylococcus aureus

2010                B.S. Chemistry

                        Grand Valley State University, Department of Chemistry

 

Grants and Fellowships:

2025-2027      NIH NCI Small Research Grant Program (R03)

Title: TIP60-chromatin remodeling complex roles in chromosome break repair.
Role: Multi-Principal Investigator. Award Amount: $100,000

2024–2025      OSU Undergraduate Research Access Innovation Seed Grant

Title: Evolution driven purifying selection in cancer cells
Role: Co-Investigator. Award Amount: $10,000

2023–2025      NIH NCI Small Research Grant Program (R03)

Title: The Role of PRMT5 in preventing intra-chromosomal deletions in cancer cells.
Role: Multi-Principal Investigator. Award Amount: $100,000

2023–2024      OSU College of Arts and Sciences NMS Exploratory Grant

Title: Investigating the role of L,D-transpeptidases in the antibiotic-resistance of Enterobacteriacea
Role: Principal Investigator. Award Amount: $40,000

2021–2023      NIH NCI Small Research Grant Program (R03)

Title: The role of chromatin remodeling factors in DNA double-strand break repair.
Role: Co-Investigator. Award Amount: $100,000

2018–2019      American Heart Association Postdoctoral Fellowship

Title: G protein-coupled receptor kinase inhibitors as therapeutics for heart failure and hypertrophy.
Role: Principal Investigator. Award Amount: $104,060

2015–2016      NIH Ruth L. Kirschstein NRSA Individual Predoctoral Fellowship (F31)

Title: Discovery of a new class of antibacterials that inhibits penicillin-binding proteins
Role: Principal Investigator. Award Amount: $85,352

2013–2014      ACS Division of Medicinal Chemistry Predoctoral Fellowship

                        Role: Principal Investigator. Award Amount: $26,000

2013                American Heart Association Midwest Affiliate Predoctoral Fellowship

                        Role: Principal Investigator. Award Amount: $52,000 (declined)

2012–2015      Chemistry-Biochemistry-Biology Interface (CBBI) Fellowship (T32)

Role: Trainee

 

Honors and Awards:

2025              OSU College of Arts and Sciences Early-Career Faculty Excellence Award

2021              OSU Marion Teaching Award

2017                Molecular Pharmacology Highlighted Trainee Author

2017                Young Chemist Society CIBA Young Scientist Travel Award

2017                Robert M. Scarborough Graduate Award for Excellence in Medicinal Chemistry

2017                The Eli J. and Helen Shaheen Graduate School Award in Science

  • Recognizes one graduate student from each division of the Graduate School

2016                The Dow Chemical Outstanding Graduate Student Award

  • Recognizes one graduate student from the department

2015                Baxter Young Investigator Award (Second Tier Winner)

2014                Oral Presentation Award, Chemistry-Biochemistry-Biology Interface Symposium

 

Publications at Ohio State:

  1. Gibson LM*, Konda P, Bliss HJ*, Nelakurti DD*, Mirzaei G, Bouley RA, Wang JJ, Petreaca RC. Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations. J. Mol. Sci. (2025), 26, 7208.
  2. Bliss H*, Bouley RA, Petreaca RC. Regulation of DNA repair gene expression by PRMT5. MicroPublication Biology (2025), Doi: 10.17912/micropub.biology.001631
  3. Al-Marrawi M*, Petreaca RC, Bouley RA. In silico protein structure analysis of PRMT5 and RUVBL1 mutations arising in human cancers. Cancer Genetics (2025) 292-293, 49-56. Doi: 10.1016/j.cancergen.2025.01.002
  4. Abe A, Hinkovska-Galcheva V, Bouley R, Bouchev P, Shayman JA. The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and phospholipidosis. J. Lipid Res. (2024) 65, 100574.
  5. Bush W*, Bosart K*, Bouley R, Petreaca RC. KDM4B mutations in human cancers. Res. – Fund. Mol. Mech. Mutagen. (2024), 829, 111866. Doi: 10.1016/j.mrfmmm.2024.111866
  6. Bosart K*, Petreaca R, Bouley R. In silico analysis of several frequent SLX4 mutations appearing in human cancers. microPublication Biology. (2024) Doi: 10.17912/micropub.biology.001216.
  7. Stan A*, Bosart K*, Kaur M*, Vo M*, Escorcia W, Yoder RJ, Bouley R, Petreaca RC. Detection of driver mutations and genomic signatures in endometrial cancers using artificial intelligence. PLOS One (2024) 19, e029914. PMID: 38408048
  8. Frank LE*, Koehler B*, Yoder RJ, Bouley RA. Testing the ability of protein-protein docking programs to model known complexes: A project for the biochemistry classroom. Chem. Ed. (2023) 100, 3968-3973. Doi: 10.1021/acs.jchemed.3c00665
  9. Watson A*, Shaffer ML*, Bouley RA, Petreaca RC. Genetic alterations of F-box DNA Helicase 1 (FBH1) in human cancers. Cancers (2023) 15, 4439. PMID: 37760409
  10. Rasheed S*, Bouley RA, Yoder RJ, Petreaca RC. Protein Arginine Methyltransferase (PRMT5) Mutations in Cancer Cells. J. Mol. Sci. (2023) 24, 6042. PMID: 37047013
  11. Hardison KL*, Hawk TM*, Bouley RA, Petreaca RC. KAT5 histone acetyltransferase mutations in cancer cells. microPublication Biology. (2022) Doi: 10.17912/micropub.biology.000676
  12. Hamid AN*, Frank LE*, Bouley RA, Petreaca RC. Pan-Cancer Analysis of Co-Occurring Mutations in RAD52 and BRCA1-BRCA2-PALB2 Axis in Human Cancers. PLOS One (2022) 13, 4299. PMID: 34503108.
  13. Pappula AL*, Gibson LM*, Bouley RA, Petreaca RC. In silico analysis of a SLC6A4 G100V mutation in lung cancers. microPublication Biology. (2022) Doi: 10.17912/micropub.biology.000645
  14. Bouley R. Redesigning a 1-Semester Biochemistry Class Using In-Class Activities to Achieve High Student Engagement. Chem. Ed. (2022) 99, 293-2949. Doi: 10.1021/acs.jchemed.2c00184
  15. Pappula AL*, Rasheed S*, Mirzaei M, Petreaca RC, Bouley RA. A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database. Cancers (2021) 13, 4299. PMID: 3450108
  16. Holub AS, Bouley RA, Petreaca RC, Husbands AY. Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analysis. J. Mol. Sci. (2020) 21, 8175. PMID: 33142932

Publications Prior to Ohio State:

  1. Martinez-Caballero S, Mahasenan KV, Kim C, Molina R, Feltzer R, Lee M, Bouley R, Hesek D, Fisher JF, Chang M, Mobashery S, Hermoso JA. Integrative Structural Biology of the Essential Penicillin-Binding Protein-1, a Component of the Divisome of Staphylococcus aureus. Struct. Biotech. J. (2021) 19, 5392. PMID: 34667534
  2. Rowlands R, Chen Q, Bouley R, Avramova L, Tesmer JJG, White A. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. Med. Chem. (2021) 64, 566-585. PMID: 33393767
  3. Bouley RA, Weinberg ZY, Waldschmidt HV, Yen YC, Larsen SD, Puthenveedu MA, Tesmer JJG. A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the m-Opioid Receptor. Pharm. (2020) 97, 392-401. PMID: 32234810
  4. Rowlands R, Cato MC, Waldschmidt HV, Bouley R, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White A. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med. Chem. Lett. (2019) 10, 1628-1634. PMID: 31857838
  5. Bouley R, Hinkovska-Galcheva V, Shayman JA, Tesmer JJG. Structural basis of lysosomal phospholipase A2 inhibition by Zn2+. Biochemistry (2019) 58, 1709-1717. PMID: 30830753
  6. Janardhanan J, Bouley R, Martinez-caballero S, Peng Z, Batuecas-Mordillo M, Meisel J, Ding D, Schroeder VA, Wolter Wa, Mahasenan K, Hermoso JA, Mobashery S, Chang M. The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant Staphylococcus aureus. Agents Chemother. (2019) 63, e02637-18. PMID: 30858202
  7. Hinkovska-Galcheva V, Kelly RJ, Manthei KA, Bouley R, Yuan W, Schwendeman A, Tesmer JJG, Shayman JA. Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2. Lipid Res. (2018) 59, 1205-1218. PMID: 29724779
  8. Waldschmidt HV, Bouley R, Kirchoff PD, Tesmer JJG, Larsen SD. Utilizing a Structure-Based Docking Approach to Develop Potent G Protein-Coupled Receptor Kinase (GRK) 2 and 5 Inhibitors. Med. Chem. Lett. (2018) 28, 1507-1515. PMID: 29627263
  9. Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao X, Koch WJ, Larsen SD, Tesmer JJG. Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Pharm. (2017) 92, 707-717. PMID: 29070696
  10. Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery, S. Conformational dynamics in Penicillin-binding protein 2a of Methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis. Am. Chem. Soc. (2017) 139, 2102-2110. PMID: 28099001
  11. Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.  Med. Chem.(2016) 59, 5011-5021. PMID: 27088777
  12. Gonzales PR, Pesesky MW, Bouley R, Ballard A, Suckow MA, Biddy BA, Wolter WR, Schroeder VA, Burnham CD, Mobashery S, Chang M, Dantas G. Synergistic, collaterally-sensitive β-lactam combinations suppress resistance in MRSA. Chem. Biol. (2015) 11, 855-861. PMID: 26268589
  13. Wang H, Lee M, Peng Z, Blazquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium. Med. Chem. (2015) 58, 4194-4203. PMID: 25923368
  14. Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WA, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. J. Am. Chem. Soc. (2015) 137, 1738-1741. PMID: 25629446
  15. Testero S, Bouley R, Fisher J, Chang M, Mobashery S. Exploration of Mild Copper-Mediated Coupling of Organotrifluoroborates in the Synthesis of Thiirane-Based Inhibitors of Matrixmetalloproteinases. Med. Chem. Lett. (2011) 21, 2675-2678. PMID: 21256011