Dr. Renee Bouley

Assistant Professor of Biochemistry 

Department of Chemistry and Biochemistry

 

 

Contact Information: 

Email: Bouley.8@osu.edu

Office: Marion Science and Engineering (MSE) 110G

 

 

 

Education and Training: 

2016–2019      Postdoctoral Research Fellow

University of Michigan, Life Sciences Institute and Department of Pharmacology

2016                Ph.D. Organic Chemistry

                        University of Notre Dame, Department of Chemistry and Biochemistry

Thesis Title: Development of New Antibacterial Agents for the Treatment of Methicillin-Resistant Staphylococcus aureus

2010                B.S. Chemistry

                        Grand Valley State University, Department of Chemistry

 

Honors and Awards:

2017                Molecular Pharmacology Highlighted Trainee Author

2017                Young Chemist Society CIBA Young Scientist Travel Award

2017                Robert M. Scarborough Graduate Award for Excellence in Medicinal Chemistry

2017                The Eli J. and Helen Shaheen Graduate School Award in Science

  • Recognizes one graduate student from each division of the Graduate School

2016                The Dow Chemical Outstanding Graduate Student Award

  • Recognizes one graduate student from the department

2015                Baxter Young Investigator Award (Second Tier Winner)

2014                Oral Presentation Award, Chemistry-Biochemistry-Biology Interface Symposium

 

Publications:

  1. Rasheed S*, Bouley RA, Yoder RJ, Petreaca RC. In silico analysis of driver PRMT5 mutations in cancer cells. J. Mol. Sci. (2023) 24, 6042. PMID:37047013
  2. Hardison KL*, Hawk TM*, Bouley RA, Petreaca RC. KAT5 histone acetyltransferase mutations in cancer cells. microPublication Biology. (2022) Doi: 10.17912/micropub.biology.000676
  3. Hamid AN*, Frank LE*, Bouley RA, Petreaca RC. Pan-Cancer Analysis of Co-Occurring Mutations in RAD52 and BRCA1-BRCA2-PALB2 Axis in Human Cancers. PLOS One (2022) 13, 4299. PMID: 34503108.
  4. Pappula AL*, Gibson LM*, Bouley RA, Petreaca RC. In silico analysis of a SLC6A4 G100V mutation in lung cancers. microPublication Biology. (2022) Doi: 10.17912/micropub.biology.000645
  5. Bouley R. Redesigning a 1-Semester Biochemistry Class Using In-Class Activities to Achieve High Student Engagement. Chem. Ed. (2022) 99, 293-2949. Doi: 10.1021/acs.jchemed.2c00184
  6. Martinez-Caballero S, Mahasenan KV, Kim C, Molina R, Feltzer R, Lee M, Bouley R, Hesek D, Fisher JF, Chang M, Mobashery S, Hermoso JA. Integrative Structural Biology of the Essential Penicillin-Binding Protein-1, a Component of the Divisome of Staphylococcus aureus. Struct. Biotech. J. (2021) 19, 5392. PMID: 34667534
  7. Pappula AL*, Rasheed S*, Mirzaei M, Petreaca RC, Bouley RA. A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database. Cancers (2021) 13, 4299. PMID: 3450108
  8. Rowlands R, Chen Q, Bouley R, Avramova L, Tesmer JJG, White A. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. Med. Chem. (2020)
  9. Holub AS, Bouley RA, Petreaca RC, Husbands AY. Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analysis. J. Mol. Sci. (2020) 21, 8175.
  10. Bouley RA, Weinberg ZY, Waldschmidt HV, Yen YC, Larsen SD, Puthenveedu MA, Tesmer JJG. Pharm. (2020) 97, 392-401. PMID: 32234810
  11. Rowlands R, Cato MC, Waldschmidt HV, Bouley R, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White A. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med. Chem. Lett. (2019) 10, 1628-1634. PMID: 31857838
  12. Bouley R, Hinkovska-Galcheva V, Shayman JA, Tesmer JJG. Structural basis of lysosomal phospholipase A2 inhibition by Zn2+. Biochemistry (2019). PMID: 30830753
  13. Janardhanan J, Bouley R, Martinez-caballero S, Peng Z, Batuecas-Mordillo M, Meisel J, Ding D, Schroeder VA, Wolter Wa, Mahasenan K, Hermoso JA, Mobashery S, Chang M. The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant Staphylococcus aureus. Agents Chemother. (2019). PMID: 30858202
  14. Hinkovska-Galcheva V, Kelly RJ, Manthei KA, Bouley R, Yuan W, Schwendeman A, Tesmer JJG, Shayman JA. Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2. Lipid Res. (2018) 59, 1205-1218. PMID: 29724779
  15. Waldschmidt HV, Bouley R, Kirchoff PD, Tesmer JJG, Larsen SD. Utilizing a Structure-Based Docking Approach to Develop Potent G Protein-Coupled Receptor Kinase (GRK) 2 and 5 Inhibitors. Med. Chem. Lett. (2018) 28, 1507-1515. PMID: 29627263
  16. Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao X, Koch WJ, Larsen SD, Tesmer JJG. Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Pharm. (2017) 92, 707-717. PMID: 29070696
  17. Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery, S. Conformational dynamics in Penicillin-binding protein 2a of Methi-cillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis. Am. Chem. Soc. (2017) 139, 2102-2110. PMID: 28099001
  18. Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.  Med. Chem.(2016) 59, 5011-5021. PMID: 27088777
  19. Gonzales PR, Pesesky MW, Bouley R, Ballard A, Suckow MA, Biddy BA, Wolter WR, Schroeder VA, Burnham CD, Mobashery S, Chang M, Dantas G. Synergistic, collaterally-sensitive β-lactam combinations suppress resistance in MRSA. Chem. Biol. (2015) 11, 855-861. PMID: 26268589
  20. Wang H, Lee M, Peng Z, Blazquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. Synthesis and Evaluation of 1,2,4-Triazolo[1,5-a]pyrimidines as Antibacterial Agents Against Enterococcus faecium. Med. Chem. (2015) 58, 4194-4203. PMID: 25923368
  21. Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WA, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Discovery of Antibiotic (E)-3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. J. Am. Chem. Soc. (2015) 137, 1738-1741. PMID: 25629446
  22. Testero S, Bouley R, Fisher J, Chang M, Mobashery S. Exploration of Mild Copper-Mediated Coupling of Organotrifluoroborates in the Synthesis of Thiirane-Based Inhibitors of Matrixmetalloproteinases. Med. Chem. Lett. (2011) 21, 2675-2678. PMID: 21256011