Publications | Benej Lab

Peer-revied journal articles:

Benej M, Hoyd R, Kreamer M, Wheeler CE, Grencewicz DJ, Choueiry F, Chan CHF, Zakharia Y, Ma Q, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Robinson LA, Singer EA, Ikeguchi AP, McCarter MD, Tinoco G, Husain M, Jin N, Tan AC, Osman AEG, Eljilany I, Riedlinger G, Schneider BP, Benejova K, Kery M, Papandreou I, Zhu J, Denko N, Spakowicz D. The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer. Cancer Res Commun. 2024 Jul 1;4(7):1690-1701. doi: 10.1158/2767-9764.CRC-23-0367. PubMed PMID: 38904265; PubMed Central PMCID: PMC11234499.

Benej M, Papandreou I, Denko NC. Hypoxic adaptation of mitochondria and its impact on tumor cell function. Semin Cancer Biol. 2024 May;100:28-38. doi: 10.1016/j.semcancer.2024.03.004. Epub 2024 Mar 30. Review. PubMed PMID: 38556040; PubMed Central PMCID: PMC11320707.

Echeverri Ruiz NP, Mohan V, Wu J, Scott S, Kreamer M, Benej M, Golias T, Papandreou I, Denko NC. Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth. Cancer Metab. 2021 Nov 8;9(1):39. doi: 10.1186/s40170-021-00275-4. PubMed PMID: 34749809; PubMed Central PMCID: PMC8577026.

Kaul K, Benej M, Mishra S, Ahirwar DK, Yadav M, Stanford KI, Jacob NK, Denko NC, Ganju RK. Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity. Front Immunol. 2021;12:753477. doi: 10.3389/fimmu.2021.753477. eCollection 2021. PubMed PMID: 34777365; PubMed Central PMCID: PMC8581492.

Moraes CR, Moraes LE, Blawut B, Benej M, Papandreou I, Denko NC, Coutinho da Silva M. Effect of glucose concentration and cryopreservation on mitochondrial functions of bull spermatozoa and relationship with sire conception rate. Anim Reprod Sci. 2021 Jul;230:106779. doi: 10.1016/j.anireprosci.2021.106779. Epub 2021 May 23. PubMed PMID: 34048998.

Benej M, Wu J, Kreamer M, Kery M, Corrales-Guerrero S, Papandreou I, Williams TM, Li Z, Graves EE, Selmic LE, Denko NC. Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors. Cancers (Basel). 2021 Apr 3;13(7). doi: 10.3390/cancers13071696. PubMed PMID: 33916656; PubMed Central PMCID: PMC8038388.

Benej M, Svastova E, Banova R, Kopacek J, Gibadulinova A, Kery M, Arena S, Scaloni A, Vitale M, Zambrano N, Papandreou I, Denko NC, Pastorekova S. CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia. Front Oncol. 2020;10:1462. doi: 10.3389/fonc.2020.01462. eCollection 2020. PubMed PMID: 32983978; PubMed Central PMCID: PMC7493625.

Benej M, Danchenko M, Oveckova I, Cervenak F, Tomaska L, Grossmannova K, Polcicova K, Golias T, Tomaskova J. Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells. Front Microbiol. 2019;10:2438. doi: 10.3389/fmicb.2019.02438. eCollection 2019. PubMed PMID: 31708904; PubMed Central PMCID: PMC6823195.

Correction for Benej et al., Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11561. doi: 10.1073/pnas.1818732115. Epub 2018 Nov 19. PubMed PMID: 30455291; PubMed Central PMCID: PMC6298097.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. PubMed PMID: 30201710; PubMed Central PMCID: PMC6196495.

Takacova M, Hlouskova G, Zatovicova M, Benej M, Sedlakova O, Kopacek J, Pastorek J, Lacik I, Pastorekova S. Encapsulation of anti-carbonic anhydrase IX antibody in hydrogel microspheres for tumor targeting. J Enzyme Inhib Med Chem. 2016;31(sup1):110-118. doi: 10.1080/14756366.2016.1177523. Epub 2016 May 3. PubMed PMID: 27140748.

Benej M, Pastorekova S, Pastorek J. Carbonic anhydrase IX: regulation and role in cancer. Subcell Biochem. 2014;75:199-219. doi: 10.1007/978-94-007-7359-2_11. Review. PubMed PMID: 24146381.

Benej M, Bendlova B, Vaclavikova E, Poturnajova M. Establishing high resolution melting analysis: method validation and evaluation for c-RET proto-oncogene mutation screening. Clin Chem Lab Med. 2011 Oct 6;50(1):51-60. doi: 10.1515/CCLM.2011.730. PubMed PMID: 21973105.

Generation and characterization of a novel genetic model of mitochondrially driven hypoxia in NSCLC: Kate Benejova, McKenzie Kreamer, Esin Bayrali Ulker, Nicholas Denko, Martin Benej. PIIO Annual Symposium, Columbus, OH, Dec 2, 2024