Selected recent publications; find ALL at
*, corresponding author; bold, our group
Qian J, Wang B, Artsimovitch I, Dunlap D, Finzi L (2024). Force and the α-C-terminal domains bias RNA polymerase recycling. Nat Commun. 15(1):7520.
Wang B, Said N, Hilal T, Finazzo M, Wahl MC*, Artsimovitch I* (2024) Transcription termination factor ρ polymerizes under stress. BioRxiv, August 18, 2023
Gjorgjevikj D, Kumar N, Wang B, Hilal T, Said N, Loll B, Artsimovitch I, Sen R, Wahl MC (2024) Widespread gene regulator Psu inhibits transcription termination factor ρ by forced hyper-oligomerization. BioRxiv, June 22, 2023
Said N, Finazzo M, Hilal T, Wang B, Selinger TM, Gjorgjevikj D, Artsimovitch I*, Wahl MC* (2024) Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation. Nat Commun. 15(1):3186.
Porter LL, Artsimovitch I*,Ramírez-Sarmiento CA* (2024) Metamorphic proteins and how to find them. Curr Opin Struct Biol. 76
Zuber P, Said N, Hilal T, Wang B, Loll B, González-Higueras J, Ramírez-Sarmiento CA, Belogurov GA, Artsimovitch I*, Wahl MC*, Knauer S* (2024) Concerted transformation of a hyper-paused transcription complex and its reinforcing protein. Nat Commun. 15, 340.
Jin Qian J, Allison Cartee, Xu W, Yan Y, Wang B, Artsimovitch I, Dunlap D, Finzi L (2024) Reciprocating RNA Polymerase batters through roadblocks. Nat Commun. 15(1):3193.
Artsimovitch I*,Ramírez-Sarmiento CA* (2022) Metamorphic proteins under a computational microscope: lessons from a fold-switching RfaH protein. Comp Struct Biotech J. 20, 5824-37.
Wang B, Svetlov D, Bartikofsky D, Wobus CE, Artsimovitch I* (2022) Going retro, going viral: experiences and lessons in drug discovery from COVID-19. Molecules, 27, 3815-23.
Mittermeier M, Wang B, Said N, Gjorgjevikj D, Wahl MC, Artsimovitch I* (2022) A non-native C-terminal extension of the β’ subunit compromises RNA polymerase and Rho functions. Mol Microbiol. 117, 871-885.
Molina AJ, Galaz-Davison P, Komives EA, Artsimovitch I*, Ramírez-Sarmiento CA* (2022) Dynamic couplings upon binding of RfaH to transcription elongation complexes. Nucleic Acids Res. 50, 6384–97.
Xu W, Yan Y, Dunlap D, Artsimovitch I, Finzi L* (2022) Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops. Nucleic Acids Res. 50, 2826-35.
Janissen R, Eslami-Mossallam B, Artsimovitch I*, Depken M*, Dekker NH* (2022) A unifying mechanistic model of bacterial transcription with three interconnected pause states and non-diffusive recovery from backtracks. Cell Rep., 39, 110749.
Wang B, Svetlov D, Artsimovitch I* (2021) NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain. Nucleic Acids Res. 49, 8822-35.
Wang B, Svetlov V, Wolf YI, Koonin EV, Nudler E, Artsimovitch I* (2021) Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides. mBio. 12, e0142321.
Chatterjee S, Chauvier A, Dandpat SS, Artsimovitch I, Walter NG* (2021) A translational riboswitch coordinates transcription-translation coupling. Proc Natl Acad Sci U S A. 18, e2023426118.
Svetlov D, Artsimovitch I* (2021) Reductionism ad absurdum: the misadventures of structural biology in the time of coronavirus. ACS Infect Dis. 7, 2948-52.
Wang B, Artsimovitch I* (2021) NusG, an ancient yet rapidly evolving transcription factor. Frontiers Microbiol. 11, 619618.
Said N, Hilal T, Sunday ND, Khatri A, Bürger J, Mielke T, Loll B, Sen R, Belogurov GA, Artsimovitch I*, Wahl MC* (2021) Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ. Science. 371, eabd1673.