In Vivo electrophysiological techniques
A triceps surae compound muscle action potential amplitude from a neonatal mouse model of spinal muscular atrophy.
Repetitive nerve stimulation (RNS)
Repetitive nerve stimulation at 3 Hz demonstrating decrement in a patient with myasthenia gravis.
Voluntary SFEMG showing muscle fiber action potential jitter and blocking (indicative of loss of fidelity of NMJ transmission).
In Vivo and In Situ Muscle Contractility
Example of a torque readout following a plantarflexion tetanic contraction (125Hz stimulation rate)
Example of loss of tetanic torque in an aged versus young rat indicative of NMJ transmission failure
Immunohistochemistry and Confocal Imaging
Neuromuscular junction staining in an aged C57BL/6J mouse.
Motoneuronal staining in pig.
In Vivo MRI Muscle Assessment
Hind limb imaging in an aged C57BL/6J mouse with region of interest identified to quantify muscle volume.