Multimodal in vivo therapy for soft tissue sarcomas
“Introduction: Soft tissue sarcomas emerge in soft tissues of the skin, vasculature, muscle, fat, and nerves. Of the many types of sarcoma, we investigated osteosarcoma and rhabdomyosarcoma, which are comparatively common in children. Osteosarcoma lines are radioresistant, while rhabdomyosarcoma lines are radiosensitive. We investigated this dynamic using combined chemotherapy and radiation therapies in an attempt to sensitize osteosarcomas to radiation.
Methods: Mouse rhabdomyosarcoma and osteosarcoma lines were injected into C57/BL6 mice subcutaneously. Mice in the experimental group received 3x4gy consecutive irradiation along with daily oral feeding of 8.25 ug of the chemotherapeutic agent BMN673. Tumor growth was measured with caliper above the hip joint of the mice.
Results: Confirmation that osteosarcoma lines are radioresistant, that rhabdomyosarcoma lines are radiosensitive, and that combined treatment of chemotherapy with radiation is more effective than either alone.
Conclusions: Combined treatment of radiation and BMN673 increases radiosensitivity of the rhabdomyosarcoma tumors.”