Zobeida Cruz-Monserrate, Ph.D.

Assistant Professor, Department of Internal Medicine

Division of Gastroenterology, Hepatology and Nutrition
400 W. 12th Ave.
2041 Wiseman Hall 
614-685-8266

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My laboratory research program is focused on studying pancreatic diseases in particular pancreatic ductal adenocarcinoma (PDAC) which is one of the most deadly human malignancies, with dismal long-term survival and limited advances in treatment. The long-term goals of my research laboratory are to develop novel strategies for the detection, prevention and treatment of PDAC and pancreatitis via uncovering unique mechanisms related to the initiation of these diseases. Towards this goal we have shown that the molecule integrin alpha6beta4, the enzyme Cathepsin E (CTSE), and pH-sensitive imaging probes are all early biomarkers of PDAC development. I have been engaged in the development of novel imaging probes that have the potential to detect and treat pancreas containing early lesions of PDAC using the enzymatic activity of CTSE using pre-clinical mouse models. This technology applies to any other diseases that express CTSE at high levels which is the case of pancreatic cancer.
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